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Recombinant Full Length Human MAP2K7 Protein, C-Flag-tagged

Cat.No. : MAP2K7-1511HFL
Product Overview : Recombinant Full Length Human MAP2K7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 47.3 kDa
AA Sequence : MAASSLEQKLSRLEAKLKQENREAR RRIDLNLDISPQRPRPTLQLPLAND GGSRSPSSESSPQHPTPPAR PRHMLGLPSTLFTPRSMESIEIDQK LQEIMKQTGYLTIGGQRYQAEINDL ENLGEMGSGTCGQVWKMRFR KTGHVIAVKQMRRSGNKEENKRILM DLDVVLKSHDCPYIVQCFGTFITNT DVFIAMELMGTCAEKLKKRM QGPIPERILGKMTVAIVKALYYLKE KHGVIHRDVKPSNILLDERGQIKLC DFGISGRLVDSKAKTRSAGC AAYMAPERIDPPDPTKPDYDIRADV WSLGISLVELATGQFPYKNCKTDFE VLTKVLQEEPPLLPGHMGFS GDFQSFVKDCLTKDHRKRPKYNKLL EHSFIKRYETLEVDVASWFKDVMAK TESPRTSGVLSQPHLPFFRTRTRPL EQKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protein Kinase
Protein Pathways : ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
Gene Name : MAP2K7 mitogen-activated protein kinase kinase 7 [ Homo sapiens (human) ]
Official Symbol : MAP2K7
Synonyms : MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4
Gene ID : 5609
mRNA Refseq : NM_145185.4
Protein Refseq : NP_660186.1
MIM : 603014
UniProt ID : O14733

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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