MAP3K2
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Official Full Name
mitogen-activated protein kinase kinase kinase 2 -
Overview
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process. -
Synonyms
MAP3K2;mitogen-activated protein kinase kinase kinase 2;MEKK2;MAP/ERK kinase kinase 2;MEKK2B;M3K2_HUMAN;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2;Mitogen activated protein kinase kinase kinase 2;OTTHUMP00000203817;OTTHUMP00000203818
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- Sf9 Cells
- HEK293
- Mammalian Cells
- GST
- Non
- Avi
- Fc
- His
- Flag
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K2-1258H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged | Insect Cells | Human | GST | Full L. |
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| MAP3K2-351H | Recombinant Human MAP3K2, GST-tagged, Active | Sf9 Cells | Human | GST |
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| MAP3K2-4506HCL | Recombinant Human MAP3K2 293 Cell Lysate | HEK293 | Human | Non |
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| MAP3K2-1358H | Recombinant Human MAP3K2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| MAP3K2-1358H-B | Recombinant Human MAP3K2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| MAP3K2-1574HFL | Recombinant Full Length Human MAP3K2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Map3k2-3929M | Recombinant Mouse Map3k2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| MAP3K2-897H | Recombinant Human MAP3K2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CACNA1B,ACVR1C,PTPRR,FGF20,MAP3K6,FLNB,Fgf15,MAP3K1,RAC3B,STK4 |
| EGFR1 Signaling Pathway | EPPK1,RALBP1,SPRY2,RGS5B,SH3BGRL,RBB4L,ABI1B,CEBPA,PTK6,PITPNA |
| ErbB1 downstream signaling | ACTR3,NCKAP1,ACTR2,CHN2,WASF2,ARF4,EGR1,EPS8,BAIAP2,ABI1 |
| Gap junction | GRB2B,PRKACAB,TUBB6,CX43,TUBA8,PRKCB,GNAS,SRC,PRKACAA,PDGFAB |
| Insulin Signaling | STXBP2,REG1A,CAP1,INPP4AA,RHOJ,GSK3AB,SNAP25A,STXBP1A,EHD1,MAP4K5 |
| GnRH signaling pathway | ATF4B1,PTK2B,MAP3K4,MAP2K7,CALM3B,PLA2G4C,MAPK8B,SRC,CALM2B,CALM2 |
| BDNF signaling pathway | KCNN2,SYN1,FRS2,CDH2,EIF4E,EEF2,CFL1,DPYSL2,DOK5,FRS3 |
| MAPK Cascade | MAP2,MBPB,MBP |
Protein Function
MAP3K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | PRKAB1,CAMK2N2,JAK2,FBXO5,DBF4B,FGFR1OP,IFNAR2,TRAF6,CCNL1,PRKAG3 |
| protein serine/threonine kinase activity | MKNK1,TTBK2,ULK1A,C9orf96,NEK9,PINK1,GRK7B,STK17B,CDK12,TSSK2 |
| ATP binding | TRIB3,KIFC3,RUNX2B,MOCS3,XRCC6,UBE2IA,DDX47,EIF2AK3,MYO6,PPP2R4 |
| protein binding | ENTPD3,IRF1,ARL2,ARNT,TRIP6,APOA2,SCAMP2,RNH1,ERCC4,MT1F |
| metal ion binding | PPP1R10,KLF16,FGD4,MEP1A.2,ZYMND12,RAF1A,CYP19A1A,PHOSPHO1,CLCA1,RHEB |
| MAP kinase kinase kinase activity | TAOK2,MOS,MAP3K14,MAP3K15,TAOK3,YSK4,EGFR,TAOK1,MAP3K6,MAP3K3 |
| protein kinase activity | DCLK1,MAP3K3,MYO3A,PIK3R4,HIPK3A,PRKAA1,TNK2B,TGFBR1B,DYRK1A,BMPR1AB |
Interacting Protein
MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.
YWHAB;YWHAE;SFN;YWHAG;STUB1;saicar
MAP3K2 Related Signal Pathway
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References
- Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
- Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
