map3k2
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 2
  • Background
  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
  • Synonyms
  • MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818
Cat.#:MAP3K2-30191THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K2
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Cat.#:MAP3K2-351HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K2, GST-tagged, Active
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Cat.#:MAP3K2-1258HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged
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Cat.#:MAP3K2-4506HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K2 293 Cell Lysate
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Involved Pathway

MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
CSNK2A1P; MAP3K2; CSNK2A1; CFL1; EEF2; FRS2; GRIP1; CNR1; KCNN2; LINGO1
EGFR1 Signaling Pathway
PTPN12; AP2A1; ABI1B; USP6NL; PITPNAA; KRT8; GRB7; PITPNA; CRKL; CEBPB
ErbB1 downstream signaling
ARF4; ABI1; CHN2; EPS8; MAP3K2; EGR1; ACTR2; BAIAP2; ACTR3; WASF2
Gap junction
TUBA8L4; PDGFD; GNA15.1; TUBB5; DRD1B; GUCY1A3; SRC; GNAI3; TUBA3A; PRKG1
GnRH signaling pathway
MAP2K3; GNRH2; MAPK12A; CALM2; CALM3B; MMP2; PRKACBB; MAP3K2; PLCB3; RAF1
Insulin Signaling
MAPK6; MAP4K1; MAP3K9; GRB10; STXBP3; RRAD; RHOJ; INPP4AA; MAP3K2; FLOT1
MAPK Cascade
MAP3K2; MAP2; MBPB; MBP
MAPK signaling pathway
GADD45BA; CACNG4; MAP3K3; MYCB; PPM1NA; PTPRR; RPS6KA3A; CACNB2A; MAPK8A; HRASB

Protein Function

MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TAE1; MCM9; RIPK4; ABCC12; GCLC; NPR1A; UBE2T; ERCC2; CHTF18; OXSR1
Function MAP kinase kinase kinase activity
Related Protein MAP3K3; MAP3K4; MAP3K5; MAP3K2; MAP3K12; STK3; TAOK1; MAP3K15; MAP3K13; MAP3K8
Function metal ion binding
Related Protein CHN1; BHLHE22; UPB1; GDPD1; LMAN2L; CYP2AD6; CYP2D26; ZFP551; ACVR2AA; B3GAT1
Function protein binding
Related Protein URI1; HOMER2; EHHADH; AMHR2; PRKD1; HIST1H2AG; RSL24D1; CIDEB; USP28; IP6K2
Function protein kinase activity
Related Protein EEF2K; TBK1; CAMK2D1; CAMK2G1; PTK2; CDK14; SYK; MAP3K3; PRPF4B; MAP2K5
Function protein kinase binding
Related Protein PTPN23; CDK5RAP1; POLA1; EEF1A2; CALM; TRAF2; CADPS; GOLGA2; RPS6KA3; CCNE1
Function protein serine/threonine kinase activity
Related Protein SMG1; GSK3B; RAF1A; NEK3; RPS6KB2; MAP4K3; TTBK2; ACVR2A; MAP4K6; RPS6KAL

Interacting Protein

MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.
YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar

MAP3K2 Related Articles

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).