Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged

• Cat.No.: MAP3K2-1258H
• Product Overview: Recombinanthuman full length MAP3K2, GST-tagged, is expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: MAP3K2 isa serine/threonine kinase that activates kinases involved in the MAP kinasesignaling pathway. The protein encoded by this gene is a member ofserine/threonine protein kinase family. This kinase preferentially activatesother kinases involved in the MAP kinase signaling pathway. This kinase hasbeen shown to directly phosphorylate and activate Ikappa B kinases, and thusplays a role in NF-kappa B signaling pathway. This kinase has also been foundto bind and activate protein kinase C-related kinase 2, which suggests itsinvolvement in a regulated signaling process.
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
• Molecular Weight: 97.2 kDa
• Specific Activity: 355 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 1.39μg/ml in acoupled assay.
• Concentration: 0.3 mg/ml
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MAP3K2
• Function: ATP binding; MAPkinase kinase kinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity
• Full Length: Full L.

Gene Information

• Gene Name: MAP3K2 mitogen-activatedprotein kinase kinase kinase 2 [ Homo sapiens ]
• Synonyms: MAP3K2; mitogen-activatedprotein kinase kinase kinase 2; MEKK2; MAPK/ERK kinase kinase 2;MEKK2B; OTTHUMP00000203817; OTTHUMP00000203818; OTTHUMP00000203819; EC2.7.11.25; MEK kinase 2; MAPKKK2; MAP/ERK kinasekinase 2
• Gene ID: 10746
• mRNA Refseq: NM_006609
• Protein Refseq: NP_006600
• MIM: 609487
• UniProt ID: Q9Y2U5
• Chromosome Location: 2q14.3
• Pathway: EGFR1 SignalingPathway; ErbB1 downstream signaling; Gap junction; GnRH signaling pathway; InsulinSignaling; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kB SignalingPathway; Trk receptor signaling mediated by the MAPK pathway