• Official Full Name
  • mediator complex subunit 11
  • Background
  • MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
  • Synonyms
  • MED11; mediator complex subunit 11; HSPC296; mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog;
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED11 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED11 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED11 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MED11 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED11

Involved Pathway

MED11 involved in several pathways and played different roles in them. We selected most pathways MED11 participated on our site, such as Mus musculus biological processes, Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mus musculus biological processes
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes

Protein Function

MED11 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding, contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED11 itself. We selected most functions MED11 had, and list some proteins which have the same functions with MED11. You can find most of the proteins on our site.
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein PPARGC1B; MED22; MED13L; MED4; MED12; CNOT2; MED7; MED26; MED10; MED20
Function protein binding
Related Protein XRCC5; MAP2K5; DDIT3; DCUN1D4; TRADD; VPS37A; KCNRG; KIAA1267; ITGB1BP1; NR2C2
Function contributes_to ubiquitin protein ligase activity
Related Protein SKP2; CUL2; FBXL17; CUL5A; FBXL18; UBXN6; C10orf46; FBXL2; FBXL3B; MED11

Interacting Protein

MED11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED11.
MED6; MED22; MED27; MED18; Med30; Med8; MED28; MED17; MED29; Ywhae; Cdk9