MED12 Protein, mediator complex subunit 12


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Official Full Name mediator complex subunit 12
Background The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
Synonyms MED12; mediator complex subunit 12; OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230; mediator of RNA polymerase II transcription subunit 12; CAG repeat protein 45; human opposite paired; OPA-containing protein; putative mediator subunit 12; activator-recruited cofactor 240 kDa component; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein, 230 kDa subunit; mediator of RNA polymerase II transcription, subunit 12 homolog; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit);
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED12-4479H Recombinant Human MED12 Protein, GST-tagged Wheat Germ GST
    Mouse MED12-9682M Recombinant Mouse MED12 Protein Mammalian Cell His
    Zebrafish MED12-3618Z Recombinant Zebrafish MED12 Mammalian Cell His

    MED12 involved in several pathways and played different roles in them. We selected most pathways MED12 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway RCAN2; ATP1A2; MED13; PIK3CD; PLCB3; FOXO1; MAP2K2; PFKFB2; CCND1; AKT1

    MED12 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription coactivator activity, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED12 itself. We selected most functions MED12 had, and list some proteins which have the same functions with MED12. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding CDX1; HNRNPC; RUVBL2; H3F3B; SPI1; RELA; POU4F1; GZF1; NFE2L2; CDX2
    RNA polymerase II transcription coactivator activity SMARCA2; PITX2; WBP2; CITED4; POU3F2; NEUROD1; TRIM28; SOX11; NCOA1; MKL1
    RNA polymerase II transcription cofactor activity MED19A; MED22; MED21; TP53BP1; PPRC1; PPARGC1B; MED24; NKX2; MDT-19; MED19
    beta-catenin binding APC2; CARM1; GSK3B; CALCOCO1; SOX17; PSEN1; CTNNA3; SOX9; PXN; DACT2
    chromatin binding TCF7L2; TWIST2; KAT2B; HMGN5; NPM2; TBL1Y; HDGF2; KIAA0101; DLX2; NKX6-1
    protein C-terminus binding ITGB3BP; HOMER3; BLOC1S2A; DLG1; SREBF2; CSK; ECM1; PROP1; SP1; PFKM
    protein binding PPP3R2; MAP6; SNRPN; STX11; MAP3K5; ACKR4; STX8; ZMYND10; CD27; MRPS27
    protein domain specific binding ARHGEF4; ICAL1; ATN1; ATP1A1; RARA; SNCA; MYO7A; FOXA2; RAB27B; CALM1
    receptor activity ERBB3B; ABP1; VMN1R52; EDAR; MED14; GABRA5; LILRB2; TIGIT; XPR1; VMN1R40
    thyroid hormone receptor binding NR0B2; MED16; TAF7; MED1; MED24; TRIP12; NSD1; HMGN3; TRIP6; MED13
    transcription coactivator activity CARM1; NCOA1; TADA2A; MAML1; TAF7L; SMARCC2; MED31; SUPT7L; NEUROG3; TAF7
    transcription cofactor activity MED4; MED16; NFE2L1; MED12; ANKRA2; SLC26A3; AIRE; CALCOCO1; THRAP3; ZFP710
    transcription factor binding PSMD4; IFI16; TFDP1B; CXXC5; SLC26A5; NAB2; WWP2; HDAC5; KAT6B; REST
    transcriptional activator activity, RNA polymerase II transcription factor binding KLF4; NR1H4; JUN; KLF14; CLOCK; LMO2; CREB1; MED12; NKX2-5; SOX10
    contributes_to ubiquitin protein ligase activity FBXL14A; KDM2BA; FBXL7; C10orf46; FBXL2; FBXL18; CUL5; ANAPC2; UBXN6; FBXL6

    MED12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED12.

    TGFBR2; Foxp3; Ywhae; Tfcp2l1; Tada2a; Kat2a

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