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MED17

  • Official Full Name

    mediator complex subunit 17

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
  • Synonyms

    MED17; mediator complex subunit 17; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD) , cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa , CRSP6; mediator of RNA polymerase II transcription subunit 17; CRSP77; D;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED17-663H Recombinant Human MED17 Mammalian Cell His
Human MED17-804H Recombinant Human MED17, GST-tagged E.coli GST C-term-350aa
Human MED17-1907H Recombinant Human MED17 Protein, GST-tagged Wheat Germ GST
Human MED17-4391HCL Recombinant Human MED17 293 Cell Lysate HEK293 N/A
Human MED17-2800H Recombinant Human MED17 protein, His-tagged E.coli His 296-651 aa
Human MED17-3451H-B Recombinant Human MED17 Protein Pre-coupled Magnetic Beads HEK293
Human MED17-3451H Recombinant Human MED17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED17-9689M Recombinant Mouse MED17 Protein Mammalian Cell His
Mouse MED17-5447M Recombinant Mouse MED17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED17-5447M-B Recombinant Mouse MED17 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MED17-2719R Recombinant Rhesus monkey MED17 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MED17-2539R-B Recombinant Rhesus Macaque MED17 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MED17-2539R Recombinant Rhesus Macaque MED17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MED17-4783Z Recombinant Zebrafish MED17 Mammalian Cell His
Chicken MED17-1427C Recombinant Chicken MED17 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MED17 involved in several pathways and played different roles in them. We selected most pathways MED17 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone signaling pathwayPLCG2;MED12L;SLC16A10;MED4;MAP2K1;MED30;PRKACB;MAPK1;AKT1

MED17 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED17 itself. We selected most functions MED17 had, and list some proteins which have the same functions with MED17. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityTDG;MED11;FOXH1;MED13A;MED13B;PPARGC1B;MED31;MED13;TP53BP1
ligand-dependent nuclear receptor transcription coactivator activityNCOA1;NCOA2;USP22;SFR1;THRAP3;HMGA1-RS1;ATXN7L3;CALCOCO1;NCOA3
protein bindingRPS6;CCDC88A;H2AFX;PDE4D;EHMT2;ARHGEF2;FAM207A;EPB41B;SLC7A1
receptor activityNLGN2;PVRL4;UNC13B;ROBO4;Pla2r1;DERL1;CD33;PAQR3A;CD46
thyroid hormone receptor bindingPRMT2;MED16;MED1;TAF11;GAS2L1;TRIP6;MED17;MED24;TAF7
transcription coactivator activityZSCAN1;SMARCA4;YAP1;KAT2B;MED6;TRIM32;KDM5A;TAF5L;TADA1
transcription cofactor activityTMF1;SUPT20H;WDR75;LDB2A;KAT2B;LDB2;TAF13;NMI;RFXANK
ubiquitin protein ligase activityUBE3C;UBE3A;RNF165;STUB1;TMEM189;FANCF;RNF180;RNF34;BTRC
vitamin D receptor bindingMED17;MED16;MED24;THRAP3;MED4;RUNX2B;RXRA;TAF11;MED30

MED17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED17.

MED10; MED19; MED29; MED22; Med30

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