med17
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  • Official Full Name
  • mediator complex subunit 17
  • Background
  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
  • Synonyms
  • MED17; mediator complex subunit 17; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD) , cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa , CRSP6; mediator of RNA polymerase II transcription subunit 17; CRSP77; D
Cat.#:MED17-1907HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED17 Protein, GST-tagged
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Cat.#:MED17-663HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MED17
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Cat.#:MED17-804HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED17, GST-tagged
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Cat.#:MED17-9689MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED17 Protein
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Cat.#:MED17-2719RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MED17 Protein, His-tagged
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Cat.#:MED17-1427CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MED17
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Cat.#:MED17-4783ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED17
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Cat.#:MED17-4391HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED17 293 Cell Lysate
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Involved Pathway

MED17 involved in several pathways and played different roles in them. We selected most pathways MED17 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED17 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
ATP2A2; RAF1; ESR1; SLC16A10; MED27; ATP1A4; CCND1; PDPK1; MDM2; MAP2K1

Protein Function

MED17 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED17 itself. We selected most functions MED17 had, and list some proteins which have the same functions with MED17. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein MED13A; RBM14; MED19A; MED31; MED4; MED21; MDT-19; MED15; NKX2; MED10
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein FGF2; USP22; PRKCB; PSMC3IP; PPARGC1B; MED17; CALCOCO1; MED14; PKN1; NCOA2
Function protein binding
Related Protein CAV1; RBKS; TMEM67; PCNP; NDUFS2; STX3; DRAM1; NTN1; EWSR1A; VCPKMT
Function receptor activity
Related Protein RTN4RL2; TMEM123; NRXN1; TNFRSF13B; ITGB3A; NLGN4B; KLRG1; ATP6AP2; KIR2DL1; KLRB1B
Function thyroid hormone receptor binding
Related Protein TRIP12; GAS2L1; MED4; NSD1; NCOR1; ZNHIT3; MED24; OASL; TAF11; GTF2B
Function transcription coactivator activity
Related Protein PARK7; RBPMS; GTF2F1; GATA4; ATF2; ELF3; KAT5; MTA1; JUP; NR1I3
Function transcription cofactor activity
Related Protein MAP3K7; MED1; ZNF865; RFXANK; PIR; NMI; LDB2A; LDB1B; ZMYND11; ZNF671
Function ubiquitin protein ligase activity
Related Protein HACE1; PARK2; UBE2KA; TRIM2; CDC34B; UHRF1; MED1; RNF2; BFAR; AKTIP
Function vitamin D receptor binding
Related Protein MED1; THRAP3; TAF11; MED14; MED24; SNW1; MED4; MED16; RUNX2B; RXRA

Interacting Protein

MED17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED17.
MED10; MED19; MED29; MED22; Med30