|Official Full Name||mediator complex subunit 27|
|Background||The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.|
|Synonyms||MED27; mediator complex subunit 27; cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa , CRSP8; mediator of RNA polymerase II transcription subunit 27; CRSP34; TRAP37; CRSP complex subunit 8; p37 TRAP/SMCC/PC2 subunit; transcriptional|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MED27 involved in several pathways and played different roles in them. We selected most pathways MED27 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Thyroid hormone signaling pathway||MAP2K2; ATP1B4; DIO1; RCAN1; PRKCB; NCOR1; FOXO1; PIK3R3; PIK3R5; PLCD1|
MED27 has several biochemical functions, for example, protein binding, transcription coactivator activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED27 itself. We selected most functions MED27 had, and list some proteins which have the same functions with MED27. You can find most of the proteins on our site.
|protein binding||ING4; RALYL; TUBA3E; CLK2; SEPT10; MBD1; FAM120B; FECH; MANBAL; DDX17|
|transcription coactivator activity||MED16; ARID1A; SUB1B; ZSCAN1; SCAND1; IL31RA; PCBD1; PER2; MTF1; FHL5|
|ubiquitin protein ligase activity||TRIM3; ARIH2; NEDD4L; ZSWIM2; MYLIP; PPIL2; UBR5; TRIM32; UBE3A; PDZRN3B|
MED27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED27 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED27.
MED10; MED19; MED22; Med30; CDK19; MED26; CDK8