mkrn1
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  • Official Full Name
  • makorin ring finger protein 1
  • Background
  • The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of;intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the;MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000 (PubMed 10843807)).
  • Synonyms
  • MKRN1; makorin ring finger protein 1; E3 ubiquitin-protein ligase makorin-1; RNF61; RING finger protein 61; FLJ21334
Cat.#:MKRN1-022HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human MKRN1 Protein, Flag-tagged
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Cat.#:MKRN1-5372HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MKRN1 Protein, GST-tagged
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Cat.#:MKRN1-895HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MKRN1, GST-tagged
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Cat.#:MKRN1-6307CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MKRN1
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Cat.#:MKRN1-9444ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MKRN1
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Cat.#:MKRN1-4300HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MKRN1 293 Cell Lysate
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Involved Pathway

MKRN1 involved in several pathways and played different roles in them. We selected most pathways MKRN1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKRN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
AP2A1; AGO1; LRRC41; SPSB2; KIF15; VPRBP; NRG4; ASB3; GAN; KLRB1B
Antigen processing: Ubiquitination &
SPSB1; ASB3; ASB2; MKRN1; ARIH2; ASB14; TRIM63; UBA5; TRIM9; HUWE1
Proteasome degradation
IWS1; FBXO44; ASB6; HUWE1; KLHL21; HECTD3; KLHL20; ASB4; UBE2L6; CMTM2A
Class I MHC mediated antigen processing &
UBE2F; RNF123; PJA2; ASB9; MKRN1; RNF182; LTN1; ASB10; FBXO3; SPSB4
presentation
RBCK1; LRRC41; RNF19B; ASB14; ERAP2; NPEPPS; UBE2F; KLHL20; DTX3L; KLHL21
Immune System
EDA; DDOST; LTF; RNF182; IFIT3; SAMHD1; SPSB1; SIGLEC5; SLAMF6; CD300LB

Protein Function

MKRN1 has several biochemical functions, for example, chromatin binding, ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKRN1 itself. We selected most functions MKRN1 had, and list some proteins which have the same functions with MKRN1. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein SMARCD3; SIN3B; SSBP1; NR5A1A; PRKCBP1L; CREB3L1; WACA; FOXC1A; ELK4; TFAM
Function ligase activity
Related Protein LTN1; TRIM11; BTR22; MARCH11; RNF114; MUL1; MARCH5; ZFP91; IRF2BP1; TRIM6
Function poly(A) RNA binding
Related Protein NGDN; APEH; DUS3L; SNRPC; CPSF4; LUC7L2; APOBEC3C; FASTKD2; TTC6; HIST1H1D
Function protein binding
Related Protein LZTS2; GRHL2; INO80B; CHAC1; UGP2; POLG2; HSPA1L; ATF1; UNKL; VAV3
Function ubiquitin-protein transferase activity
Related Protein TRIP12; MARCH2; KLHL20; BIRC5A; LNX2B; ZFP91; NHLRC1; RNF6; UBE2D2A; UBE3C
Function zinc ion binding
Related Protein MKRN1; ZFAND3; UMPS; ADAM20; UQCRC2A; GM757; RBM4.1; LMO4; KPNB1; MYLIPB

Interacting Protein

MKRN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKRN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKRN1.
TP53; CDKN1A; UBC; UBE2D3; ctc; X; UBE2W; EXOSC8; DUSP23