mmp20
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  • Official Full Name
  • matrix metallopeptidase 20
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
  • Synonyms
  • MMP20; matrix metallopeptidase 20; AI2A2; MMP-20; matrix metalloproteinase-20; enamel metalloproteinase; matrix metalloproteinase 20 (enamelysin);
Cat.#:MMP20-162HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP20, Catalytic Domain
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Cat.#:MMP20-541HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP20 Protein, His-tagged
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Cat.#:Mmp20-1881MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp20 protein, His & T7-tagged
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Cat.#:MMP20-9917MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP20 Protein
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Cat.#:MMP20-2791RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MMP20 Protein, His-tagged
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Cat.#:MMP20-4276HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP20 293 Cell Lysate
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Involved Pathway

MMP20 involved in several pathways and played different roles in them. We selected most pathways MMP20 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen degradation, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
COL1A2; MMP13; PLEC; ABHD1; BMP1B; COL6A3; COL4A4; COL4A3; CTSL2; COL8A2
Collagen degradation
ELANE; MMP20; COL23A1; MMP10; COL9A1; COL25A1; MGC174155; MGC174152; EMID2; CTSB
Collagen formation
PPIB; EMID2; COL9A3; P3H2; COL2A1; COL5A2; CTSS; COL3A1; LEPRE1; TLL1
Degradation of the extracellular matrix
COL9A3; MGC174857; CTSB; ADAM15; MMP10; TLDC2; COL13A1; ELANE; KLK7; MMP13
Extracellular matrix organization
MMP12; CTRB1; COL28A1; MFAP3; DAG1; MMP17; COL5A3A; PCOLCE; LOC100686744; BGNA
Matrix Metalloproteinases
MMP10; MMP25; MMP19; MMP26; MMP12; MMP8; TIMP2; MMP17; MMP23B; BSG

Protein Function

MMP20 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP20 itself. We selected most functions MMP20 had, and list some proteins which have the same functions with MMP20. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein EFCAB1; SLIT2; PEF1; aLA; PCDH1G9; ZZEF1; ANXA3B; RHOT2; MYL4; CAPSL
Function metalloendopeptidase activity
Related Protein ADAMTS12; MMP11; TLL1; ADAM10B; BMP1; ZMPSTE24; BMP1B; NRD1B; MMP1; ADAM25
Function protein binding
Related Protein IRX1; ATP6V0A2; APOBEC3F; UBA7; FAM133A; USP49; FASTK; DDX17; FAM59A; TRIM27
Function zinc ion binding
Related Protein SIAH2L; NR2C2; EWSR1B; FTR14; USP16; TRIM13; PCGF6; ZNF146; BTR06; BRF1A

MMP20 Related Articles

Satchell, PG; Anderton, X; et al. Conservation and variation in enamel protein distribution during vertebrate tooth development. JOURNAL OF EXPERIMENTAL ZOOLOGY 294:91-106(2002).

MMP20 Related Gene Family

MMPs