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MRPL10

Official Full Name

mitochondrial ribosomal protein L10
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.
Synonyms

MRPL10; mitochondrial ribosomal protein L10; 39S ribosomal protein L10, mitochondrial; 39S ribosomal protein L10; mitochondrial; L10MT; MGC17973; MRP L8; MRP L10; MRPL8; RPML8; 39S ribosomal protein L10 mitochondrial; 39S ribosomal protein L10 mitochondrial precursor; MRPL 10; L8mt; 39S ribosomal protein L8, mitochondrial; MRP-L8; MRP-L10;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPL10-977H	Recombinant Human MRPL10, His-tagged	E.coli	His	1-261aa	$319 / 25ug
Human	MRPL10-4199HCL	Recombinant Human MRPL10 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MRPL10-5554H	Recombinant Human MRPL10 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRPL10-6377HF	Recombinant Full Length Human MRPL10 Protein, GST-tagged	In Vitro Cell Free System	GST	261 amino acids	Inquiry
Rhesus Macaque	MRPL10-2831R	Recombinant Rhesus monkey MRPL10 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MRPL10-2651R	Recombinant Rhesus Macaque MRPL10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MRPL10-2651R-B	Recombinant Rhesus Macaque MRPL10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MRPL10-2146Z	Recombinant Zebrafish MRPL10	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRPL10 Related Articles

MRPL10 involved in several pathways and played different roles in them. We selected most pathways MRPL10 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mitochondrial translation	MTFMT;MRPS28;CHCHD1;GFM2;MRRF;MRPL50;MRPL37;MRPL10;MRPS24
Mitochondrial translation elongation	MRPL38;GADD45GIP1;TSFM;ICT1;MRPL50;MRPS28;MRPS34;MRPL47;MRPS33
Mitochondrial translation initiation	MRPL39;MRPL51;DAP3;MRPL37;GADD45GIP1;MRPL47;MRPS28;MRPL28;AURKAIP1
Mitochondrial translation termination	MRPL53;MRPL48;MRPS35;MRPS24;MRPS34;MRPS33;MRPL42;MRPS23;MRPL47
Organelle biogenesis and maintenance	CNGA5;MRPL38;IFT20;MRPS31;RAB3IP;TTC30A;MRPS36;TNPO1;WDR19
Ribosome	RPS10-NUDT3;MRPL9;RPS27;RPL26L1;RPLP2L;MRPL33;RPS18;RPL10L;MRPS12

MRPL10 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL10 itself. We selected most functions MRPL10 had, and list some proteins which have the same functions with MRPL10. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	C2orf15;PAN3;RALYL;RPS27A;SNRPD2;NKRF;RPL10A;PKN2;NOL10
protein binding	EHMT2;PVRL4;PI4K2A;GYG1;FGF12;C12orf49;CALM2;GUCY1A3;AXIN2
structural constituent of ribosome	RPS27A;RPL32;RPL5B;MRPL36;MRPL14;RPL13;RPL5A;RPS5;MRPS2

MRPL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL10.

TCF4; REL; KLHL12; FAM9B; PNMA1; USP22; ICT1; MRPL50; MRPL9; MRPL1

Han, MJ; Cimen, H; et al. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION 78:48-54(2011).

Koc, EC; Yang, YJ; et al. NAD plus -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of mitochondrial ribosomal protein L10. FASEB JOURNAL 24:-(2010).