MTA2
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Official Full Name
metastasis associated 1 family, member 2 -
Overview
MTA1 (metastasis associated gene 1) was identified in a differential screening of a cDNA library of metastatic and nonmetastatic adenocarcinoma cell lines (1), and was subsequently found to be an integral member of the nucleosome remodeling and deacetylat -
Synonyms
MTA2;metastasis associated 1 family, member 2;metastasis associated gene family, member 2 , MTA1L1;metastasis-associated protein MTA2;MTA1 L1;MTA1-L1 protein;metastasis-associated 1-like 1;metastasis-associated protein 2;metastasis -associated gen
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Avi
- Fc
Involved Pathway
MTA2 involved in several pathways and played different roles in them. We selected most pathways MTA2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | RBBP7,APPL2,SPRY2,TNIP1,JUND,WNK1,RALBP1,EPPK1,STXBP1A,KRT17 |
| RNA Polymerase I Promoter Clearance | MTA1,MBD3B,TAF1C,RRN3,CHD4,CD3EAP,GATAD2B,MBD3A,TAF1B,TAF1D |
| HDACs deacetylate histones | MTA3,GATAD2AB,GATAD2B,ANO9A,MTA1,ARID4A,PHF21A,HMG20B,MBD3B,CHD4A |
| Gene Expression | ZIK1,TSNAX,ZNF461,GTF3AB,SKIB,APEH,PRDM7,FAM36A,HNRNPL2,CD3EAP |
| Chromatin organization | CARM1,TADA2B,ANO9A,CCDC101,KDM3A,SMARCA4,KAT8,SAP18,MBD3,TADA3 |
| RNA Polymerase I Transcription Initiation | UBTF,GATAD2B,MBD3A,CHD4,MTA3,MBD3,MBD3B,RRN3,CHD4A,GATAD2A |
| Chromatin modifying enzymes | KDM5D,ING5B,SMYD3,SMARCD3B,KDM4A,SMARCD1,PADI3,SMYD2,YEATS4,MBD3A |
| RNA Polymerase I Transcription | TAF1B,PTRFB,MBD3B,GATAD2A,PTRF,TAF1D,GATAD2AB,MTA3,MBD3A,UBTF |
Protein Function
MTA2 has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA2 itself. We selected most functions MTA2 had, and list some proteins which have the same functions with MTA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | SMARCC2,RBBP4,MBD3,HDAC2,SMARCA4,ACTL6A,SMARCC1,HDAC1,ACTB,GATAD2B |
| histone deacetylase activity | HDAC3,HDAC9B,HDAC9,ATXN3L,HDAC6,HDAC4,HDAC1,HDAC8,SIRT2,NACC2 |
| zinc ion binding | S100A12,VPS29,KDM5D,ZNRF1,MARCH5,RNF138,LIMD1,ZYX,ADAMTS3,SH3RF1 |
| contributes_to nucleosomal DNA binding | ACTL6A,SMARCC2,RBBP4,ACTB,CHD4,SMARCB1,SMARCC1,HDAC1,SMARCA4,HDAC2 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | ACTL6A,SMARCC2,SMARCB1,RBBP4,GATAD2B,MBD3,CHD4,SMARCC1,SMARCA4,HDAC2 |
| RNA polymerase II repressing transcription factor binding | GSC,TCF7L2,BBS1,RBBP8,BBS5,GATA6,MKKS,PROL1,TTC8,MIXL1 |
| protein binding | ANLN,TWSG1,MRFAP1,RTP3,FAM164C,IL23,BABAM1,MYOT,SEMA4C,PPM1A |
| RNA polymerase II transcription factor binding | TBX3,GATA2A,CREBBP,CHST13,GSC,HCLS1,GATA1A,ATF4,ZFPM1,PITX2 |
| transcription factor activity, transcription factor binding | LDB1A,LDB2A,ASCL1A,CRY1,LDB1B,PER1,TP63,ASCL1,HIF1A,CRY2 |
Interacting Protein
MTA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA2.
HDAC1;HDAC2;MBD3;PARK7
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