mta2
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  • Official Full Name
  • metastasis associated 1 family, member 2
  • Background
  • MTA1 (metastasis associated gene 1) was identified in a differential screening of a cDNA library of metastatic and nonmetastatic adenocarcinoma cell lines (1), and was subsequently found to be an integral member of the nucleosome remodeling and deacetylat
  • Synonyms
  • MTA2; metastasis associated 1 family, member 2; metastasis associated gene family, member 2 , MTA1L1; metastasis-associated protein MTA2; MTA1 L1; MTA1-L1 protein; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis -associated gen
Cat.#:MTA2-294HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTA2 Protein, His-tagged
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Cat.#:MTA2-1071HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTA2, GST-tagged
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Cat.#:MTA2-26HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTA2 protein, GST-tagged
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Cat.#:MTA2-10162MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MTA2 Protein
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Cat.#:MTA2-2890RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MTA2 Protein, His-tagged
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Cat.#:MTA2-12725ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTA2
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Involved Pathway

MTA2 involved in several pathways and played different roles in them. We selected most pathways MTA2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
SMARCD1; HMG20B; SUZ12; PHF2; CAPNS2; ING5A; KDM4C; ARID5B; EED; SMARCA4
Chromatin organization
MSL2A; KDM4B; SMARCD3B; PADI2; EPC1; C3orf75; MSL2B; SMARCB1A; JADE1; ING3
EGFR1 Signaling Pathway
SH3BGRL; DOK2; KRT7; GRB10; EPS8; TNIP1; USP6NL; ERRFI1; JUND; ELF3
Gene Expression
RPP38; ZNF143A; ZNF124; ZNF331; SURF1; TYW5; TRIM28; TAF1L; ZNF664; RPP14
HDACs deacetylate histones
SUDS3; ANO9A; PHF21A; ARID4A; MBD3B; BRMS1; MTA1; SAP30L; CHD4A; GATAD2B
RNA Polymerase I Promoter Clearance
CHD4A; MTA2; EHMT2; MTA3; MBD3B; TAF1A; CD3EAP; MTA1; EFCAB11; TAF1C
RNA Polymerase I Transcription
GATAD2A; TAF1D; TAF1B; MTA3; MBD3B; GATAD2AB; UBTF; TAF1C; GATAD2B; CBX3
RNA Polymerase I Transcription Initiation
GATAD2AB; MBD3B; GATAD2B; MTA1; MBD3A; UBTF; MTA3; MBD3; CHD4A; GATAD2A

Protein Function

MTA2 has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA2 itself. We selected most functions MTA2 had, and list some proteins which have the same functions with MTA2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RBBP4; ACTL6A; SMARCC2; CHD4; SMARCE1; SMARCC1; ACTB; MBD3; HDAC2; SMARCB1
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein ACTB; GATAD2B; MBD3; SMARCC2; RBBP4; ACTL6A; SMARCB1; SMARCC1; HDAC2; MTA2
Function RNA polymerase II repressing transcription factor binding
Related Protein BBS10; GTF2A2; BBS7; SP1; MIXL1; TTC8; RBPJ; BBS1; MTA1; TBX5A
Function RNA polymerase II transcription factor binding
Related Protein GATA1; ZFPM2A; TAL1; SPI1; WWP2; T; PITX2; CREBBP; MKX; GATA2A
Function histone deacetylase activity
Related Protein MTA2; HDAC5; HDAC9B; NACC2; HDAC11; HDAC2; ATXN3L; HDAC4; HDAC10; HDAC7
Function contributes_to nucleosomal DNA binding
Related Protein SMARCC2; RBBP4; MBD3; SMARCB1; CHD4; ACTL6A; HDAC2; MTA2; ACTB; SMARCC1
Function protein binding
Related Protein TH; IFNA2; EPHA10; LIN9; TMF1; AGBL4; OTUB1; TAB1; COG2; CLIC2
Function transcription factor activity, sequence-specific DNA binding
Related Protein VAV1; CREBZF; RARGA; UBN2B; SLC26A3; SMAD3; ZFP13; PA2G4A; NR1H5; HOXD10
Function transcription factor activity, transcription factor binding
Related Protein PER2; ASCL1B; CRY2; FOXO1; TP63; LDB1B; ASCL1; LDB2B; PER1; ASCL1A
Function zinc ion binding
Related Protein CALR; ZPR1; ADAM22; ZNF385A; G2E3; KDM5B; RBM14A; FANCL; ZRANB1; BHMT

Interacting Protein

MTA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA2.
HDAC1; HDAC2; MBD3; PARK7