mylk
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  • Official Full Name
  • myosin light chain kinase
  • Background
  • This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3 region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
  • Synonyms
  • MYLK; myosin light chain kinase; myosin, light polypeptide kinase; myosin light chain kinase, smooth muscle; MLCK; MLCK1; MYLK1; smMLCK; smooth muscle myosin light chain kinase; telokin; kinase-related protein; KRP; AAT7; MLCK108; MLCK210; MSTP083; FLJ122
Cat.#:MYLK-5820HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYLK Protein, GST-tagged
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Cat.#:MYLK-1509HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYLK protein, His & GST-tagged
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Cat.#:MYLK-27838THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYLK
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Cat.#:MYLK-355HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Myosin Light Chain Kinase, GST-tagged, Active
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Cat.#:Mylk-1510MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mylk protein, His & T7-tagged
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Cat.#:MYLK-7009CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYLK
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Cat.#:MYLK-696HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Myosin Light Chain Kinase, GST-tagged
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Cat.#:MYLK-4017HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYLK 293 Cell Lysate
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Involved Pathway

MYLK involved in several pathways and played different roles in them. We selected most pathways MYLK participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
PLCD3; PRKACBB; PDE1B; SPHK2; TACR3A; GNA11; HTR4; ADCY1A; GRIN1B; AGTR1B
cGMP-PKG signaling pathway
ATP1A3; CREB3L1; MEF2C; Adcy4; ATP1B1; KCNJ8; ATP1A1; INSR; AGTR1B; KCNMB3
Vascular smooth muscle contraction
NPR2; ADORA2AB; PLCB3; MAPK1; MAP2K2A; PLA2G3; MAPK3; CACNA1D; NPR1; CALM3B
Focal adhesion
ELK1; CAV2; FLT1; PPP1CBL; RAP1B; IGF1; MYL12A; ROCK2A; RAC1B; SPP1
Platelet activation
GP1BB; NOS3; ARHGEF1; PLCB3; PPP1R12A; APBB1IP; MAPK11; STIM1; PRKCZ; PLCB2
Regulation of actin cytoskeleton
PPP1R12B; CHRM5B; PIP5K1BB; ARAF; ITGAX; ARHGEF7A; FGF8A; HRAS; MAPK3; FGFR2
Oxytocin signaling pathway
CACNB1; CACNG4; MAP2K2; GUCY1B3; RHOA; CAMK2A; EEF2K; GNAI3; ELK1; NPR2
Gastric acid secretion
SLC26A7; CA2; KCNJ16; PLCB4; KCNJ1; CAMK2B; ATP1A2; PLCB3; PRKCA; MYLK4

Protein Function

MYLK has several biochemical functions, for example, ATP binding, actin binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK itself. We selected most functions MYLK had, and list some proteins which have the same functions with MYLK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PTK7A; MYO1E; MAP4K2; RAD17; ABCD4; ATP2B3A; ATP1A1A.1; SUCLG1; ACVRL1; TARS2
Function actin binding
Related Protein TMOD2; ALDOA; ARPC1A; ABLIM2; PHACTR3A; AKAP5; TWF2B; BAIAP2L1; VMHCL; PPP1R9B
Function calmodulin binding
Related Protein VAMP2; MYO1G; CAMK4; ADD1; CAMK2G1; SPTAN1; AKAP5; KCNN1A; CAMK1G; CNN2
Function metal ion binding
Related Protein NUDT8; GZF1; ZDHHC13; KDM2AA; TROVE2; CDKAL1; ZFP553; HBBE2; COQ7; RPP21
Function myosin light chain kinase activity
Related Protein MYLK; MYLK2; MYLK3
Function protein binding
Related Protein SNRPG; RIPK1L; SH3GLB2; RBMS1; KRTAP3-1; Car8; RCHY1; BRD3; MT3; LPXN

Interacting Protein

MYLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK.
GOPC; MYL12A; NCK1; PIK3R1; GRB2; CTTN; HSPB1; q7ard3_yerpe; q7cje7_yerpe; ahpC; exuR; tbpA1; q8d0g3_yerpe; npm_alk