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MYO5A

Official Full Name

myosin VA (heavy chain 12, myoxin)
Overview

This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of;actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA;translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene;cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or;Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported,;but the full-length nature of some variants has not been determined.
Synonyms

MYO5A; myosin VA (heavy chain 12, myoxin); MYH12, myosin VA (heavy polypeptide 12, myoxin); unconventional myosin-Va; GS1; MYO5; myosin heavy chain 12; myosin V; myosin; heavy polypeptide kinase; myoxin; MYR12; myosin-12; myosin-Va; myosin, heavy polypep;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYO5A-8026H	Recombinant Human MYO5A protein, His & T7-tagged	E.coli	His/T7	Ser1531~Val1855 (Accession # Q9Y4I1)	Inquiry
Human	MYO5A-4654H	Recombinant Human MYO5A Protein (Ser1531-Val1855), N-His tagged	E.coli	N-His	Ser1531-Val1855	Inquiry
Human	MYO5A-5841H	Recombinant Human MYO5A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MYO5A-10340M	Recombinant Mouse MYO5A Protein	Mammalian Cell	His		Inquiry
Mouse	MYO5A-5860M	Recombinant Mouse MYO5A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Myo5a-1808M	Recombinant Mouse Myo5a Protein, His-tagged	E.coli	N-His	Ser1529-Val1853	Inquiry
Mouse	MYO5A-5860M-B	Recombinant Mouse MYO5A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MYO5A-3866R	Recombinant Rat MYO5A Protein	Mammalian Cell	His		Inquiry
Rat	MYO5A-3525R	Recombinant Rat MYO5A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Myo5a-1809R	Recombinant Rat Myo5a Protein, His-tagged	E.coli	N-His	Ser1504-Val1828	Inquiry
Rat	MYO5A-3525R-B	Recombinant Rat MYO5A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	MYO5A-6852C	Recombinant Chicken MYO5A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MYO5A involved in several pathways and played different roles in them. We selected most pathways MYO5A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MYO5A has several biochemical functions, for example, ATP binding, ATP-dependent protein binding, Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO5A itself. We selected most functions MYO5A had, and list some proteins which have the same functions with MYO5A. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ROS1;CNTN1B;MKNK2B;EPHA8;ACVR2AA;SPATA5;ULK1;KHK;YME1L1
ATP-dependent protein binding	MYO5A;DNAJC5;PRNP;STX1A;SAE1;DDX39B
Rab GTPase binding	STX4A;HACE1;EVI5;RHOBTB3;NSF;RABGAP1L;LLGL1;AP3M1;RAB3GAP1
SNARE binding	VAMP3;EXOC3;CAPN10;YKT6;UVRAG;VAMP5;SEC22A;TRIM9;EXOC3L
actin binding	FGD4;MYOT;GMFG;MYH9;DSTN;MYO6;DMD;SNTB2;SPTB
calcium ion binding	MAN1B1;EGF;KCNIP2;GUCA1C;JAG2;PCDH2AC;AASS;VSNL1A;THBS2
calcium-dependent protein binding	NRXN1;MYO5A;SYN1;VPS37C;TNNC1;STX2;S100A11;CPNE3;SEC31A
calmodulin binding	CAMSAP1L1;MAP2;ATP2B4;PDE1C;RASGRF2;TRPV1;MYO9B;NOS3;SLC9A1
microfilament motor activity	MYH13;MYO1E;MYO5A;MYO3A;MYO7A;MYH3;MYO9B;MYH10;MYO1D
motor activity	MYH11;MYH11A;KLC1;KIF18B;KIF1C;MYO1H;DYNLL2;DYNC2LI1;MYH1
nucleotide binding	NELFE;GNAI2A;SRPK1B;CPEB1A;RBFOX3;EPHB4B;SEPT9B;HSPA12A;ATP2A2A
poly(A) RNA binding	NOL11;PIGC;GRWD1;HNRNPUL1;CLTC;CLNS1A;PRPF6;LRP1;ANKRD17
protein binding	ERO1LB;DAPP1;STAG3;CIB3;ZBTB24;RAB22A;GNG5;GDI1;KIF27
protein dimerization activity	NPAS2;HER8.2;HER7;FAP;TCF23;ATOH1;ASCL2;LDB1A;ERBB2
protein heterodimerization activity	PDGFB;HIST1H2BH;PRSS28;BAXB;H2AFB3;ODZ4;SLC3A1;HIST1H3F;BAD
syntaxin-1 binding	SNAP25B;MYO5A;DAPK1;SYBU;UNC13A;VAMP3;RNF40;NSF;STXBP3

MYO5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO5A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO5A.

Grin1; Grin2b; Slc17a9; Nos1; NPHP4; Csf1; SNCA; Hmga2; Ywhae; Ywhab