MDH
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Official Full Name
Malate Dehydrogenase
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Overview
Malate dehydrogenase (EC 1.1.1.37) (MDH) is an enzyme in the citric acid cycle that catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (this is a reversible reaction). Malate dehydrogenase is not to be confused with malic enzyme, which catalyzes the conversion of malate to pyruvate, producing NADPH. Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate. -
Synonyms
Cytoplasmic malate dehydrogenase; Cytosolic malate dehydrogenase; Malate dehydrogenase 1; Malate dehydrogenase 1 NAD (soluble); Malate dehydrogenase 2; Malate dehydrogenase 2 NAD (mitochondrial); MDH 1; MDH 2; MDH; MDH1; MDH2; MDHA; MDHm; MDHs; MMDH; Mor 1; Mor 2; Mor1; MOR2; SMDH; Soluble malate dehydrogenase; Malate dehydrogenase; rMDH; EC 1.1.1.37;
- Recombinant Proteins
- Native Proteins
- Assay Kits
- Bacillus methanolicus
- Bacillus subtilis
- Bacillus subtilis (strain 168)
- Brucella abortus (strain S19)
- Escherichia coli (strain K12)
- Pig
- E. coli or Yeast
- E.coli
- Porcine Heart
- Yeast
- His
- SUMO
- Myc
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Bacillus methanolicus | mdh-5628B | Recombinant Bacillus methanolicus mdh protein, His-tagged | Yeast | His | 2-381aa |
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| Bacillus methanolicus | mdh-3964B | Recombinant Bacillus methanolicus mdh protein, His-SUMO & Myc-tagged | E.coli | His-SUMO & Myc | 2-381aa |
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| Bacillus subtilis | MDH-0736B | Recombinant Bacillus subtilis MDH protein, His-tagged | E. coli or Yeast | His |
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| Bacillus subtilis (strain 168) | mdh-3213B | Recombinant Bacillus subtilis (strain 168) mdh protein, His-tagged | E.coli | His | 2-312aa |
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| Brucella abortus (strain S19) | mdh-3214B | Recombinant Brucella abortus (strain S19) mdh protein, His-SUMO & Myc-tagged | E.coli | His-SUMO & Myc | 1-320aa |
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| Escherichia coli (strain K12) | mdh-3215E | Recombinant Escherichia coli (strain K12) mdh protein, His-tagged | E.coli | His | 1-312aa |
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| Pig | MDH-38P | Active Native Porcine Malate dehydrogenase | Porcine Heart | N/A |
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| Kit-0544 | MDH Activity Colorimetric Assay Kit | N/A |
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| Kit-2078 | Malate Dehydrogenase Assay Kit | N/A |
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MDH involved in several pathways and played different roles in them. We selected most pathways MDH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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MDH has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MDH itself. We selected most functions MDH had, and list some proteins which have the same functions with MDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
MDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH.
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