NCL

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NCL

Official Full Name nucleolin
Background Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Synonyms NCL; nucleolin; C23;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ncl-4314M Recombinant Mouse Ncl Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human NCL-985H Recombinant Human NCL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human NCL-05H Recombinant Human NCL protein, His-tagged Yeast His
    Human NCL-06H Recombinant Human NCL protein, His-tagged E.coli His
    Human NCL-07H Recombinant Human NCL protein, His-tagged Insect Cell His
    Human NCL-08H Recombinant Human NCL protein, GST-tagged Wheat Germ GST
    Human NCL-1174HCL Recombinant Human NCL cell lysate N/A
    Human NCL-124H Recombinant Human NCL Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NCL-27593TH Recombinant Human NCL, His-tagged E.coli His
    Human NCL-442H Recombinant Human NCL Protein, His/GST-tagged E.coli His/GST
    Mouse NCL-10477M Recombinant Mouse NCL Protein Mammalian Cell His
    Mouse NCL-1493M Recombinant Mouse NCL Protein, His-tagged E. coli His
    Mouse Ncl-444M Recombinant Mouse Ncl Protein, His-tagged E.coli His
    Cynomolgus Monkey NCL-728C Recombinant Cynomolgus NCL Protein, His-tagged Mammalian Cell His
    Chicken NCL-6817C Recombinant Chicken NCL Mammalian Cell His
    Zebrafish NCL-4534Z Recombinant Zebrafish NCL Mammalian Cell His

    NCL involved in several pathways and played different roles in them. We selected most pathways NCL participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathogenic Escherichia coli infection CDC42; TLR5; TUBB6; WAS; TUBA1B; TUBAL3; KRT18; ROCK2; CTTN; FYN

    NCL has several biochemical functions, for example, ErbB-4 class receptor binding, RNA binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCL itself. We selected most functions NCL had, and list some proteins which have the same functions with NCL. You can find most of the proteins on our site.

    Function Related Protein
    ErbB-4 class receptor binding NCL
    RNA binding THOC5; OASL1; RPP14; RPL7; SRSF12; SRP68; RPL7A; PATL2; RBM24A; NOL3
    calcium ion binding NECAB3; PLCB2; PCDHA10; PCDHA9; SYT7B; MYO5A; UMODL1; STIM1; ANXA3A; COL4A3BPA
    histone binding H3F3A; NAP1L2; HIST2H3C1; HIST4H4; USP49; USP3; PHF21A; CD1D; RNF20; RNF168
    identical protein binding CLDN14; HSPB1; UBQLN1; ACTG1; DAPK1; B2M; UGP2; ORAI1; PARP1; SEPT7
    laminin binding PLEKHA2; LGALS1; ITGB1; ECM1; CTSS; AGRN; TINAGL1; ITGA9; GPC1; LRRC15
    nucleotide binding RAF1A; ABCC8; HSPA4A; RAB11BB; HIPK3A; PRKACBB; ACTB1; SNRPB2; MYHZ1.2; LTB4R
    poly(A) RNA binding AGO2; SUMO1; SREK1; UTP18; RPL29; HSP90AA1; DIMT1; HNRNPAB; SRSF10; BRIX1
    protein C-terminus binding MLLT4; SDC1; FOXN3; PPP2CA; MKI67; CALCOCO1; DAB2; PEX26; HOMER3; JAK2
    protein binding MZF1; CDK2AP1; PVRL3; EXOSC8; DDX47; PAX3; COBL; GALR2; KIF4A; TUBB4A
    rRNA primary transcript binding RPF1; NCL; IMP4; PTRF
    selenocysteine insertion sequence binding SECISBP2; NCL
    single-stranded DNA binding PMS1; MEIOB; RPA3; CDC45; NABP2; LONP1; RTF1; HSPD1; WBP11; RAD51AP1
    telomeric DNA binding XRCC5; PIF1; POT1A; TP53BP1; TINF2; OBFC1; CDAN1; TEN1; TERFA; SMG6

    NCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCL here. Most of them are supplied by our site. Hope this information will be useful for your research of NCL.

    COL18A1; MDM2

    Santacatterina, F; Chamorro, M; et al. Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases. JOURNAL OF TRANSLATIONAL MEDICINE 13:-(2015).
    Han, SQ; Meng, YC; et al. The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. MABS 6:403-408(2014).

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