ndufs3
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.
  • Synonyms
  • NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 3 (30kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; CI 30; comp
Cat.#:NDUFS3-1239HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS3, GST-tagged
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Cat.#:NDUFS3-29480THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS3, T7 -tagged
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Cat.#:NDUFS3-833HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS3, T7-tagged
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Cat.#:NDUFS3-10543MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS3 Protein
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Cat.#:NDUFS3-2989RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDUFS3 Protein, His-tagged
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Cat.#:NDUFS3-3938CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDUFS3
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Cat.#:NDUFS3-2504ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS3
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Cat.#:NDUFS3-3896HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS3 293 Cell Lysate
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Involved Pathway

NDUFS3 involved in several pathways and played different roles in them. We selected most pathways NDUFS3 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
COX17; NDUFC2-KCTD14; UQCRB; NDUFB2; NDUFS8A; ctaG; ATP5S; COX7B; ATP5H; ATP5J
Metabolic pathways
NDUFS7; ADSSL; DHRS13L1; G6PC; LTC4S; PCYT1AA; NDUFB5; SQLEA; DCXR; NNT
Non-alcoholic fatty liver disease (NAFLD)
SDHB; NDUFS5; NDUFA12; INS2; SOCS3; PRKAB2; NDUFA10; NDUFS4; SDHD; NDUFA4
Alzheimers disease
FAS; PPP3R2; TNF; Atp5g2; NDUFA1; UQCRFS1; ITPR1; CALM3; APH1B; NCSTN
Parkinsons disease
PRKACG; COX7A1; ATP5F1; SDHD; NDUFA1; PPIF; NDUFS7; ATP5G1; NDUFA5; NDUFS5
Huntingtons disease
UQCR10; CREB3L2; NDUFA1; COX6B2; COX5A; UQCRQ; DNAL1; POLR2B; DNAIC2; NDUFA2

Protein Function

NDUFS3 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS3 itself. We selected most functions NDUFS3 had, and list some proteins which have the same functions with NDUFS3. You can find most of the proteins on our site.
Function
Related Protein
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFAB1; NDUFB2; NDUFA12; NDUFB4; NDUFV3; NDUFC2-KCTD14; NDUFS1; NDUFS3; NDUFA9; NDUFS8
Function NADH dehydrogenase activity
Related Protein NDUFA9A; NDUFS3; NDUFA13; NDUFA9
Function electron carrier activity
Related Protein PTGES2; ACOX1; CYP1A2; UGDH; ETFA; AOX3; ALDH4A1; ACADS; MAOB; CYBA
Function protein binding
Related Protein PDE4D; FAM189B; GAD2; ITGB7; GABARAPL2; EFCAB11; TRIM32; NME7; EPB42; HOOK2

Interacting Protein

NDUFS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS3.
NDUFS2; NDUFA2; NDUFAF3; MT-ND6; VCAM1

NDUFS3 Related Articles

Massoz, S; Larosa, V; et al. Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism. MITOCHONDRION 19:365-374(2014).
Boyle, KE; Hwang, H; et al. Gestational Diabetes Is Characterized by Reduced Mitochondrial Protein Expression and Altered Calcium Signaling Proteins in Skeletal Muscle. PLOS ONE 9:-(2014).