nefm
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  • Official Full Name
  • neurofilament, medium polypeptide
  • Background
  • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
  • Synonyms
  • NEFM; neurofilament, medium polypeptide; NFM; NEF3; NF-M; neurofilament medium polypeptide; neurofilament 3; 160 kDa neurofilament protein; neurofilament triplet M protein; neurofilament-3 (150 kD medium); neurofilament, medium polypeptide 150kDa;
Cat.#:NEFM-294HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NEFM
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Cat.#:NEFM-6816HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEFM protein, His-tagged
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Cat.#:NEFM-10564MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NEFM Protein
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Cat.#:NEFM-3953RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NEFM Protein
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Cat.#:NEFM-3737CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEFM
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Cat.#:NEFM-1520BTag:N/A
Source (Host):Bovine Spinal CordSpecies:Bovine
Product nameNative Bovine NEFM
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Cat.#:NEFM-179BTag:N/A
Source (Host):Species:Bovine
Product nameNative bovine NEFM
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Cat.#:NEFM-3883HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NEFM 293 Cell Lysate
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Involved Pathway

NEFM involved in several pathways and played different roles in them. We selected most pathways NEFM participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)
PPP3CA; NEFL; MAPK13; RAC1; NEFH; APAF1; BID; SLC1A2; PPP3R2; DAXX

Protein Function

NEFM has several biochemical functions, for example, microtubule binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFM itself. We selected most functions NEFM had, and list some proteins which have the same functions with NEFM. You can find most of the proteins on our site.
Function
Related Protein
Function microtubule binding
Related Protein RGS14; SKA2; KIF2A; KIF1B; NEIL2; MAPRE2; PRNP; KIF4A; FNTA; RACGAP1
Function protein binding
Related Protein GPKOW; BMP2; GMIP; HIST1H2AH; DRAM1; UTP11L; EPN3; MLLT4; ZKSCAN1; TSNAX
Function structural constituent of cytoskeleton
Related Protein TUBA1B; TUBA8L2; DMD; BICD1; TUBA1C; BKJ; SORBS3; AGRN; TUBB2A; KRT2

Interacting Protein

NEFM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFM here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFM.
RB1; FOS; JUN; ETS1; NR4A2; RAC3; MDM2; SQSTM1; SMAD2; Hap1; TNIK; q9wmx2-pro_0000037548; DNAJA2; PTBP3; CALD1; IQCB1

NEFM Related Articles

Penney, KL; Sinnott, JA; et al. Association of Prostate Cancer Risk Variants with Gene Expression in Normal and Tumor Tissue. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 24:255-260(2015).
Barboni, B; Russo, V; et al. Gestational stage affects amniotic epithelial cells phenotype, methylation status, immunomodulatory and stemness properties. STEM CELL REVIEWS AND REPORTS 10:725-741(2014).