NFATC3
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Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -
Overview
The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an -
Synonyms
NFATC3;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3;nuclear factor of activated T-cells, cytoplasmic 3;NFAT4;NFATX;NF-ATc3;T cell transcription factor NFAT4;nuclear factor of activated T-cells c3 isoform IE-Xa
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFATC3-01H | Recombinant Human NFATC3 Protein, His-tagged | E.coli | Human | His | 900-1035 aa | |
| NFATC3-27538TH | Recombinant Human NFATC3 | Wheat Germ | Human | Non | 1068 amino acids |
|
| NFATC3-29252TH | Recombinant Human NFATC3 | Wheat Germ | Human | Non | 80 amino acids |
|
| NFATC3-3856HCL | Recombinant Human NFATC3 293 Cell Lysate | HEK293 | Human | Non |
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| NFATC3-236H | Recombinant Human NFATC3 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| NFATC3-339HF | Recombinant Full Length Human NFATC3 Protein | In Vitro Cell Free System | Human | Full L. 1068 amino acids |
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| Nfatc3-4389M | Recombinant Mouse Nfatc3 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| NFATC3-5888H | Recombinant Human NFATC3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
NFATC3 involved in several pathways and played different roles in them. We selected most pathways NFATC3 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | KALRN,DCC,GFRA1,FRS3,DCX,RASGEF1A,RAC2,PEA15,EGF,EPHA8 |
| B Cell Receptor Signaling Pathway | MAP4K1,PDPK1A,IKBKG,FOS,CD81,HDAC5,VAV3,PIK3AP1,ITPR2,MALT1 |
| Hepatitis B | TGFB3,BCL2,CASP8,IFNA2,PRKCG,TGFBR1,ATF4,SMAD4,STAT2,IFNA13 |
| Wnt signaling pathway | RHOAD,GPC4,MAPK8B,SIAH2L,PLCB2,FZD9B,Fzd4,SFRP4,WNT4,RAC2 |
| MAPK signaling pathway | GNA12A,CACNA1C,CASP3B,SOS1,TAB2,MAP4K1,GNG12,CACNA2D3,ARRB2A,CACNA2D2 |
| T cell receptor signaling pathway | PAK2,PDCD1,CBLB,MAPK9,VAV3,NFKBIA,VAV2,CD8B1,CD28,GRB2 |
| Oxytocin signaling pathway | CAMK1G,CACNG7,GNAO1,MAPK3,PPP3CA,Adcy4,CAMK1,PIK3CG,CALM4,NPR2 |
| HTLV-I infection | CCND2,AKT2,POLD4,TP53,HLA-DRB4,EGR1,POLD1,POLB,FOSL1,HRAS |
| cGMP-PKG signaling pathway | MEF2A,CALM4,SLC8A1,MAPK3,BAD,ATF4,PLCB1,PDE2A,PIK3R3,PPP3CB |
Protein Function
NFATC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC3 itself. We selected most functions NFATC3 had, and list some proteins which have the same functions with NFATC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | Ar,FEZF2,POU1F1,ATOH1,CTCFL,TLX1,DDIT3,FOSL1A,FEZF1,JUNBA |
| transcription factor binding | SMAD2,DNAJA3,TRERF1,KAT2A,PPP1R13B,MDFIC,SRF,HES2,SP1,TAF7 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PHOX2B,PPARA,FOS,NEUROD1,TFAP4,TFE3,PITX2,PLSCR1,SIX1,ONECUT1 |
| chromatin binding | RNF20,RBPJ,HDAC7A,TRIM24,ATF2,HIF1AB,APTX,GATA4,CHD7,GATA2B |
| protein binding | PDGFB,AP5S1,CEP104,TBKBP1,DGKQ,RANGAP1,OGG1,ORAI1,CCNB1,TCEA2 |
Interacting Protein
NFATC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC3.
CDK6;RAF1
NFATC3 Related Signal Pathway
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References
- Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
- Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).
