nfatc3
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  • Official Full Name
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
  • Background
  • The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms
  • NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; nuclear factor of activated T-cells, cytoplasmic 3; NFAT4; NFATX; NF-ATc3; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa
Cat.#:NFATC3-27538THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFATC3
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Cat.#:NFATC3-29252THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFATC3
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Cat.#:NFATC3-3856HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFATC3 293 Cell Lysate
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Involved Pathway

NFATC3 involved in several pathways and played different roles in them. We selected most pathways NFATC3 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PLA2G4A; MAP4K2; RPS6KA6; MAP3K1; GADD45AB; Fgf15; CACNB4; MAP3K14; MRAS; ARRB2
cGMP-PKG signaling pathway
GNAI3; GUCY1A3; NFATC1; RHOA; IRS4; GNA12; ATP1A3; ATP2B4; SLC8A1; CREB3L2
Wnt signaling pathway
PRKCA; NLK; INVS; MAPK10; PLCB2; MYCB; RAC2; RUVBL1; WIF1; SOST
Axon guidance
SPRED2; ARPC1A; DPYSL2B; EGF; RND1L; SEMA3E; JAK2; CHL1; PLXNA1; EPHB4A
T cell receptor signaling pathway
FOS; PAK1; NFKBIB; MAP3K14; SHB; NRAS; FYN; IFNG; VAV1; TEC
B cell receptor signaling pathway
RAP2A; NFKBIA; BTK; PPP3R2; IKBKB; MAP2K1; PLCG2; HRAS; HDAC5; CD79B
Oxytocin signaling pathway
PLA2G4D; ITPR1; ROCK1; MEF2C; PIK3CG; ACTG1; MYL6; PPP3CB; FOS; PRKACG
Hepatitis B
IFNA7; CCNA2; STAT2; BAX; CASP10; RB1; AKT2; IL6; Casp3; PRKCB
HTLV-I infection
CDC27; ETS1; IL2RG; STAT5B; NFATC4; TBP; HLA-DQB1; GPS2; WNT8B; MRAS

Protein Function

NFATC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC3 itself. We selected most functions NFATC3 had, and list some proteins which have the same functions with NFATC3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NFKB2; TTC6; PGR; HLTF; SMAD6; CHD7; NACC2; POU2F2; HNRNPK; SREBF2
Function chromatin binding
Related Protein POLA1; UBE2T; SIN3A; IFT74; NCAPD2; ZMYND11; APITD1; REST; GATA3; ZFP354B
Function protein binding
Related Protein SOCS5; PLCB4; APEX1; AHCYL2; SRPK2; MYO1C; ANLN; NAP1L4; NKG7; POLR1C
Function transcription factor binding
Related Protein ERCC3; JUNBB; FOXO1; CHCHD2; PPP1R13L; KAT6B; PSMD10; RBL1; ZEB1; TWIST1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOXI1; PITX1; NR4A3; ELF4; ARNT2; NFIB; RELA; CEBPZ; ISL1; BSX

Interacting Protein

NFATC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC3.
CDK6; RAF1

NFATC3 Related Articles

Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).