ngfrap1
Share
  • Official Full Name
  • nerve growth factor receptor (TNFRSF16) associated protein 1
  • Background
  • The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Coexpression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed.
  • Synonyms
  • NGFRAP1; nerve growth factor receptor (TNFRSF16) associated protein 1; protein BEX3; Bex; BEX3; brain expressed; X linked 3; DXS6984E; HGR74; NADE; brain expressed, X-linked 3; brain-expressed X-linked protein 3; ovarian granulosa cell protein (13kD); p75NTR-associated cell death executor; ovarian granulosa cell 13.0 kDa protein HGR74; nerve growth factor receptor-associated protein 1
Cat.#:NGFRAP1-10642MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NGFRAP1 Protein
+Inquiry
Cat.#:NGFRAP1-3023RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NGFRAP1 Protein, His-tagged
+Inquiry
Cat.#:NGFRAP1-1191HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NGFRAP1 cell lysate
+Inquiry

Involved Pathway

NGFRAP1 involved in several pathways and played different roles in them. We selected most pathways NGFRAP1 participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NGFRAP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neurotrophin signaling pathway
NGFRAP1; CAMK2G; RIPK2; CALML3; PIK3R3; HRAS; TRAF6; NGF; GSK3B; RHOA

Protein Function

NGFRAP1 has several biochemical functions, for example, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NGFRAP1 itself. We selected most functions NGFRAP1 had, and list some proteins which have the same functions with NGFRAP1. You can find most of the proteins on our site.
Function
Related Protein
Function protein kinase binding
Related Protein CCNB1; PPP1R15A; GRB2; MEF2A; NSF; PXN; CAMK2N2; FOXM1; CCNE2; EEF1A1

Interacting Protein

NGFRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NGFRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NGFRAP1.
CCDC116; FSD2; NECAB2; GOLGA8F; GOLGA8DP; USHBP1; CTNNBL1