• Official Full Name
  • NLR family, pyrin domain containing 7
  • Background
  • This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • NLRP7; NLR family, pyrin domain containing 7; NACHT, leucine rich repeat and PYD containing 7 , NALP7; NACHT, LRR and PYD domains-containing protein 7; CLR19.4; NOD12; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; FLJ94610; HYDM; MGC126470; MGC126471; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains containing protein 7; NALP7; NALP7_HUMAN; Nucleotide-binding oligomerization domain protein 12; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PYRIN-containing APAF1-like protein 3
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NLRP7, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NLRP7 Protein, His-tagged

Involved Pathway

NLRP7 involved in several pathways and played different roles in them. We selected most pathways NLRP7 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD pathway

Protein Function

NLRP7 has several biochemical functions, for example, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP7 itself. We selected most functions NLRP7 had, and list some proteins which have the same functions with NLRP7. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein MAP2K2; STK31; AK4; RPS6KA3A; MAPK9; NME2B.1; PIK3C3; MARK1; GMPS; CENPE