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NOD1

Official Full Name

nucleotide-binding oligomerization domain containing 1
Overview

Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain (C
Synonyms

NOD1; nucleotide-binding oligomerization domain containing 1; CARD4, caspase recruitment domain family, member 4; nucleotide-binding oligomerization domain-containing protein 1; CLR7.1; NLR family; CARD domain containing 1; NLRC1; nucleotide binding olig;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NOD1-1318H	Recombinant Human NOD1 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	NOD1-3772HCL	Recombinant Human NOD1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NOD1-1769H	Recombinant Human NOD1 protein, His & T7-tagged	E.coli	His/T7	Ala612~Asp826 (Accession # Q9Y239)	Inquiry
Human	NOD1-3895H	Recombinant Human NOD1 Protein (Ala612-Asp826), N-His tagged	E.coli	N-His	Ala612-Asp826	Inquiry

Involved Pathway
Protein Function
Interacting Protein
NOD1 Related Articles
NOD1 Related Research Area

NOD1 involved in several pathways and played different roles in them. We selected most pathways NOD1 participated on our site, such as Activated TLR4 signalling, Cytokine Signaling in Immune system, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activated TLR4 signalling	DUSP7;CHUK;DUSP6;CHST13;TIRAP;JUN;DUSP3B;CREB1;TAB1
Cytokine Signaling in Immune system	FGFR1B;IRAK3;TRIM10;TRIM3;DUSP5;GBP4;PAQR3A;PTPRA;JAK3
Epithelial cell signaling in Helicobacter pylori infection	ATP6V0E1;GIT1;NFKBIA;MAPK11;ATP6V0A1;SRC;ATP6V0A4;MAPK12;NFKB1
Immune System	LAIR2;STIM1B;NLRP4E;SIGIRR;TNIP2;UBE2U;IFIT2;CTSB;IFIT10
Innate Immune System	NLRP4;DUSP3;SIGLEC15;S100B;FCN1;WIPF3;POLR3H;CFHL1;CFHL4
Interleukin-1 signaling	PELI1;PELI2;IL1RN;TNIP2;NOD1;PELI3;IRAK3
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
MAP kinase activation in TLR cascade	DUSP3B;TNIP2;NOD1;DUSP3

NOD1 has several biochemical functions, for example, ATP binding, CARD domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by NOD1 itself. We selected most functions NOD1 had, and list some proteins which have the same functions with NOD1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	FANCM;ABCB5;PAN3;FER;DHX32;ARAF;HIPK4;DNA2;PTK6B
CARD domain binding	NOD1;CARD9;CARD14;C9orf89;MAVS;RIPK2;CARD11
cysteine-type endopeptidase activator activity involved in apoptotic process	BCL2L13;GNB2L1;CTSH;BAD;NOD1;MAPK9;PYCARD;APAF1;CTSC
identical protein binding	ACTN2;CLDN6;NFKBIA;CALCA;COL18A1;VWA2;CASP6;CALHM1;G6PDX
peptidoglycan binding	TLR2;PGLYRP3;PGLYRP1;NLRP3;PGLYRP4;NOD1;TREM2;RNASE7;PGLYRP2
protein binding	MYH9;CNNM3;ENPP1;PSMD4;POU1F1;MSI2;DOK1;LINC01588;ZAP70
protein homodimerization activity	TDG;TERFA;BOKB;RAB11FIP4;PDCD6;MAP3K9;SNX6;Trl;IDH1

NOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOD1.

RIPK2; HSP90AA1; sspH2; a8k1f4_human; b3ktt5_human; b4dyc6_human; HSPA1A; CASP9; PSMD2; FKBP5; PTGES3; CDC37; Usp19

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).

Xie, JS; Belosevic, M; et al. Functional characterization of receptor-interacting serine/threonine kinase 2 (RIP2) of the goldfish (Carassius auratus L.). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:76-85(2015).

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