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NR2E3

Official Full Name

nuclear receptor subfamily 2, group E, member 3
Overview

This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

NR2E3; nuclear receptor subfamily 2, group E, member 3; photoreceptor-specific nuclear receptor; PNR; rd7; RP37; ESCS; MGC49976; NR2 E3; Nuclear receptor subfamily 2 group E member 3; Photoreceptor specific nuclear receptor; Rd 7; Retina specific nuclear receptor; Retinal degeneration 7; RNR; retina-specific nuclear receptor; photoreceptor cell-specific nuclear receptor variant 1;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|GST
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NR2E3-1358H	Recombinant Human NR2E3, His-tagged	E.coli	His	C-term-322aa	$319 / 25ug
Human	NR2E3-1090H	Recombinant Human NR2E3 protein, His & GST-tagged	E.coli	His/GST	Met1~Asn410	Inquiry
Human	NR2E3-3711HCL	Recombinant Human NR2E3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NR2E3-1583H	Recombinant Human NR2E3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	NR2E3-6083H	Recombinant Human NR2E3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NR2E3-6739HF	Recombinant Full Length Human NR2E3 Protein, GST-tagged	In Vitro Cell Free System	GST	322 amino acids	Inquiry
Mouse	Nr2e3-4490M	Recombinant Mouse Nr2e3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	NR2E3-1756Z	Recombinant Zebrafish NR2E3	Mammalian Cell	His		Inquiry
Chicken	NR2E3-6163C	Recombinant Chicken NR2E3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NR2E3 Related Articles

NR2E3 involved in several pathways and played different roles in them. We selected most pathways NR2E3 participated on our site, such as Gene Expression, Generic Transcription Pathway, Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	MYBL1;NR1D2A;TXN;THOC4;ZNF624;UHRF1;ZNF658;ZFP1;MED20
Generic Transcription Pathway	TRIM33;HELZ2;ZNF483;ZNF184;SURF1;ZNF26;NR2F1B;MED25;MED13B
Nuclear Receptor transcription pathway	NRBF2B;NR2E3;NR6A1A;NR1D2A;NR4A2A;RARG;NR2F1B;NR1D2B;ESRRG

NR2E3 has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR2E3 itself. We selected most functions NR2E3 had, and list some proteins which have the same functions with NR2E3. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	HNF4G;PPARDB;NR5A1B;PPARA;NR5A1;NR2E3;RORCB;NR2F1A;PGR
protein binding	NDUFA13;ZNF286A;LRSAM1;MTUS2;LINC01588;PALM;NRF1;PRSS2;TGFA
sequence-specific DNA binding	MSXB;FOXC1A;TAF2;HOXC12;THRB;ZNF238;HOXD9A;SMAD3A;HOXB6A
steroid hormone receptor activity	RXRB;RORB;RARAB;RXRGA;ESRRB;RARAA;NR4A2;NR2E1;PPARAB
zinc ion binding	CBLL1;RFPL3;XRN2;TRIM35-22;ADAM28;TGFB1I1;ADAM8;GATA5;PRKCBP1L

NR2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR2E3.

CDK9; DHX30; HDAC3; NCOR1; RBL1; RBBP4; TBL3; HDAC1

Bracci, PM; Zhou, M; et al. Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study. CANCER 118:5384-5394(2012).

Kautzmann, MAI; Kim, DS; et al. Combinatorial Regulation of Photoreceptor Differentiation Factor, Neural Retina Leucine Zipper Gene Nrl, Revealed by in Vivo Promoter Analysis. JOURNAL OF BIOLOGICAL CHEMISTRY 286:28247-28255(2011).