NR4A3 Protein, nuclear receptor subfamily 4, group A, member 3


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Official Full Name nuclear receptor subfamily 4, group A, member 3
Background This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as;a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different;versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene;and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on;chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding;Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple;transcript variants encoding different isoforms have been found for this gene.
Synonyms NR4A3; nuclear receptor subfamily 4, group A, member 3; nuclear receptor subfamily 4 group A member 3; CHN; CSMF; MINOR; NOR1; Chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen induced nuclear orphan receptor; Mitogen-induced nuclear orphan receptor; Neuron derived orphan receptor 1; Neuron derived orphan receptor; Neuron-derived orphan receptor 1; NR4A3_HUMAN; Nuclear hormone receptor NOR-1; Nuclear hormone receptor NOR1; TEC; Translocated in extraskeletal chondrosarcoma; OTTHUMP00000022774; OTTHUMP00000022775; OTTHUMP00000022776; cho
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR4A3-1494H Recombinant Human TEC (Active), GST-tagged Sf9 Insect Cell GST
    Human NR4A3-3706HCL Recombinant Human NR4A3 293 Cell Lysate HEK293 N/A
    Human NR4A3-6097H Recombinant Human NR4A3 Protein, GST-tagged Wheat Germ GST
    Rat NR4A3-4072R Recombinant Rat NR4A3 Protein Mammalian Cell His
    Rat Nr4a3-7992R Recombinant Rat Nr4a3 protein, His & T7-tagged E.coli His/T7
    Zebrafish NR4A3-7691Z Recombinant Zebrafish NR4A3 Mammalian Cell His

    NR4A3 involved in several pathways and played different roles in them. We selected most pathways NR4A3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer PML; CCNT2; ETV7; PRCC; PBX3; PBX1; ZEB1; LMO2; Pdgfa&Pdgfb; JMJD1C

    NR4A3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A3 itself. We selected most functions NR4A3 had, and list some proteins which have the same functions with NR4A3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOXJ2; NFATC2; ATF7; NKX6-1; PLAG1; LEF1; CTCFL; PATZ1; ZNF718; CEBPB
    core promoter sequence-specific DNA binding CRY1; TP53; MLL1; TOP1; NR1D2; SIRT1; ESR2; ATF4; H2AFY; RORA
    histone acetyltransferase binding KAT2B; TRIM68; EPAS1; TP53; EID1; CEBPB; ZBTB7A; HIF1A; ETS1; CREB1
    protein binding ORAI2; GHRL; ACAD9; FLOT2; ATG13; ARL6IP1; RBM17; NPM1; CSGALNACT2; MAU2
    protein homodimerization activity AP1S2; MBL1; HMOX1; RAB11FIP4A; NOG; P2RX7; PARK7; ZFP365; INHBB; VPS25
    protein kinase binding CDKN2A; Cd24a; POLA1; TRAF2; DCX; RPS19; CENPJ; AKAP5; KCNQ3; SFN
    steroid hormone receptor activity NR5A1; NR1D2A; RXRG; THRA; NR1D2; ESR2A; NR5A1B; NR2E3; RORCB; RARAA
    thyroid hormone receptor activity THRB; THRAA; NR1D4A; NR1H4; NR1D4B; NR4A3; THRA; BRD8; NR1D2A; NR1I3
    transcription coactivator binding PASD1; TERT; NR4A3; ZBTB49; RORA
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOXA1; CRX; RAX; NCOA3; SMAD2; MYOG; PBX1; PITX2; E2F4; EBF4
    zinc ion binding ZNRF2A; SYVN1; ZSWIM7; TRIM26; MLL1; TRIM7; FTR14; ZDHHC20; MKRN4; KLF7

    NR4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A3.

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