| Description : |
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
69.3 kDa |
| AA Sequence : |
MHDSIRFGNVDMPCVQAQYSPSPPG SSYAAQTYSSEYTTEIMNPDYTKLT MDLGSTEITATATTSLPSISTFVEG YSSNYELKPSCVYQMQRPLIKVEEG RAPSYHHHHHHHHHHHHHHQQQHQQ PSIPPASSPEDEVLPSTSMYFKQSP PSTPTTPAFPPQAGALWDEALPSAP GCIAPGPLLDPPMKAVPTVAGARFP LFHFKPSPPHPPAPSPAGGHHLGYD PTAAAALSLPLGAAAAAGSQAAALE SHPYGLPLAKRAAPLAFPPLGLTPS PTASSLLGESPSLPSPPSRSSSSGE GTCAVCGDNAACQHYGVRTCEGCKG FFKRTVQKNAKYVCLANKNCPVDKR RRNRCQYCRFQKCLSVGMVKEVVRT DSLKGRRGRLPSKPKSPLQQEPSQP SPPSPPICMMNALVRALTDSTPRDL DYSRYCPTDQAAAGTDAEHVQQFYN LLTASIDVSRSWAEKIPGFTDLPKE DQTLLIESAFLELFVLRLSIRSNTA EDKFVFCNGLVLHRLQCLRGFGEWL DSIKDFSLNLQSLNLDIQALACLSA LSMITERHGLKEPKRVEELCNKITS SLKDHQSKGQALEPTESKVLGALVE LRKICTLGLQRIFYLKLEDLVSPPS IIDKLFLDTLPFTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
