Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NRCAM

Official Full Name

neuronal cell adhesion molecule
Overview

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene. Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

NRCAM; KIAA0343; MGC138845; MGC138846;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
Fc
GST
hFc
His
His (Fc)
Avi
His|GST
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NRCAM-30412TH	Recombinant Human NRCAM	Wheat Germ	N/A	110 amino acids	Inquiry
Human	NRCAM-180H	Recombinant Human NRCAM Protein, Fc-tagged	HEK293	Fc		Inquiry
Human	NRCAM-544H	Recombinant Human NRCAM	Mammalian Cell	His		Inquiry
Human	NRCAM-1220HCL	Recombinant Human NRCAM cell lysate		N/A		Inquiry
Human	NRCAM-1665H	Recombinant Human NRCAM protein, His & GST-tagged	E.coli	His/GST	Gln25~Arg143 (Accession # Q92823)	Inquiry
Human	NRCAM-8675H	Recombinant Human NRCAM protein, hFc-tagged	HEK293	hFc	Gln25-Gln1167	Inquiry
Human	NRCAM-6113H	Recombinant Human NRCAM Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NRCAM-3677H-B	Recombinant Human NRCAM Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NRCAM-3677H	Recombinant Human NRCAM Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	NRCAM-583H	Recombinant Human NRCAM protein, His-tagged	HEK293	His	Gln25-Gln1167	Inquiry
Human	NRCAM-4737H	Recombinant Human NRCAM Protein (Gln25-Asn600), C-Fc tagged	Mammalian cells	C-Fc	Gln25-Asn600	Inquiry
Chicken	NRCAM-6818C	Recombinant Chicken NRCAM	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NRCAM Related Articles

NRCAM involved in several pathways and played different roles in them. We selected most pathways NRCAM participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NRCAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell adhesion molecules (CAMs)	CLDN19;ICAM3;CLDN22;F11R.1;CD274;LRRC4C;JAM3B;CLDN5;ICOS

NRCAM has several biochemical functions, for example, ankyrin binding, protein binding, protein binding involved in heterotypic cell-cell adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by NRCAM itself. We selected most functions NRCAM had, and list some proteins which have the same functions with NRCAM. You can find most of the proteins on our site.

Function	Related Protein
ankyrin binding	PTBP3;FLNC;KCNQ2;NRCAM;OBSCN;KCTD6;SLC4A1;SPTBN1;KCNJ11
protein binding	ATP5F1;CECR2;FLOT1;EMID2;FAM127A;ILKAP;REV1;IL33;ROBO2
protein binding involved in heterotypic cell-cell adhesion	GLDN;NFASC;NRCAM

NRCAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRCAM here. Most of them are supplied by our site. Hope this information will be useful for your research of NRCAM.

HSPA12A; valS; MAGI3; MACF1; FRMD5

Devaux, JJ; Odaka, M; et al. Nodal proteins are target antigens in Guillain-Barre syndrome. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 17:62-71(2012).

Pollard, JD; Armati, PJ; et al. CIDP - the relevance of recent advances in Schwann cell/axonal neurobiology. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:15-23(2011).