| Description : |
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4 |
| Molecular Mass : |
91.2kD |
| AA Sequence : |
QMISALEVPLDPKLLEDLVQPPTIT QQSPKDYIIDPRENIVIQCEAKGKP PPSFSWTRNGTHFDIDKDPLVTMKP GTGTLIINIMSEGKAETYEGVYQCT ARNERGAAVSNNIVVRPSRSPLWTK EKLEPITLQSGQSLVLPCRPPIGLP PPIIFWMDNSFQRLPQSERVSQGLN GDLYFSNVLPEDTREDYICYARFNH TQTIQQKQPISVKVISAKSSRERPP TFLTPEGNASNKEELRGNVLSLECI AEGLPTPIIYWAKEDGMLPKNRTVY KNFEKTLQIIHVSEADSGNYQCIAK NALGAIHHTISVRVKAAPYWITAPQ NLVLSPGEDGTLICRANGNPKPRIS WLTNGVPIEIAPDDPSRKIDGDTII FSNVQERSSAVYQCNASNEYGYLLA NAFVNVLAEPPRILTPANTLYQVIA NRPALLDCAFFGSPLPTIEWFKGAK GSALHEDIYVLHENGTLEIPVAQKD STGTYTCVARNKLGMAKNEVHLEIK DATWIVKQPEYAVVQRGSMVSFECK VKHDHTLSLTVLWLKDNRELPSDER FTVDKDHLVVADVSDDDSGTYTCVA NVDDIEGRMDEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSV LTVLHQDWLNGKEYKCKVSNKALPA PIEKTISKAKGQPREPQVYTLPPSR EEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK* |
| Endotoxin : |
Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
