nrp2
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  • Official Full Name
  • neuropilin 2
  • Background
  • Vascular Endothelial Growth Factor (VEGF) is a potent mitogen for vascular endothelial cells. It significantly influences vascular permeability and is a strong angiogenic protein. VEGF probably also plays a role in neovasularization under physiological conditions. A potent synergism between VEGF and bFGF in the induction of angiogenesis has been observed. Due to its influences on vascular permeability, VEGF may be involved in altering blood-brain-barrier functions under normal and pathological conditions.
  • Synonyms
  • NRP2; neuropilin 2; neuropilin-2; VEGF165R2; neuropilin-2b(0); neuropilin-2a(17); neuropilin-2a(22); receptor for VEGF165 and semaphorins class3; vascular endothelial cell growth factor 165 receptor 2; NP2; NPN2; PRO2714; MGC126574
Cat.#:NRP2-508MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse NRP2 Protein, His-tagged
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Cat.#:Nrp2-492RTag:His
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Neuropilin 2, His-tagged
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Cat.#:NRP2-273HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP2, Fc tagged
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Cat.#:NRP2-818HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP2, His tagged
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Cat.#:NRP2-8250HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRP2 protein, His & T7-tagged
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Cat.#:NRP2-10899MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Nrp2 protein, Fc-tagged
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Cat.#:Nrp2-956MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Nrp2 Protein, Fc Chimera
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Cat.#:NRP2-4085RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NRP2 Protein
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Cat.#:Nrp2-8251RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrp2 protein, His & GST-tagged
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Cat.#:Nrp2-954RTag:Fc
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Nrp2 Protein, Fc Chimera
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Cat.#:NRP2-5857CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NRP2
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Cat.#:NRP2-937HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP2 cell lysate
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Involved Pathway

NRP2 involved in several pathways and played different roles in them. We selected most pathways NRP2 participated on our site, such as Axon guidance, Developmental Biology, L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
KBTBD7; ARPC2; SRGAP1; EPHA5; CSF2; FGF18B; PPP3R1; GDNF; COL9A3; EPHB2
Developmental Biology
SCN2B; EBF1; FGF8B; MEF2B; MED22; NR5A1; DUSP1; RHOGA; CHL1; PLXND1
L1CAM interactions
KCNQ3; RANBP9; EZRA; CNTN1; SCN8A; CD24; SCN4A; DCX; SCN2B; DLG3
Neurophilin interactions with VEGF and VEGFR
NRP2; NRP1A; NRP2B; NRP2A
NrCAM interactions
NRP2
Signal Transduction
PMCH; PTH; STRAP; PPEF1; IFT88; RXFP2B; CCNT2A; PDK2; STARD13; GPR37B
Signaling by VEGF
DSCAMA; NRP2A; SHB; JUPA; AXL; NRP2; NRP2B
Signaling events mediated by VEGFR1 and VEGFR2
NRP2

Protein Function

NRP2 has several biochemical functions, for example, cytokine binding, growth factor binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP2 itself. We selected most functions NRP2 had, and list some proteins which have the same functions with NRP2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine binding
Related Protein CXCR4; KITB; Fzd4; CHRD; CSF1RA; CRLF1; IFNGR1; CNTFR; NRP1; IL17F
Function growth factor binding
Related Protein LIFR; RHBDF2; HTRA1A; SDCBP; NRP2; HTRA1B; BMPR2; OSMR; ACVR1C; A2M
Function heparin binding
Related Protein LIPI; BSPH1; NDNF; SERPINA10; SLIT2; AAMP; ECM2; ELANE; CTGFB; FGF9
Function metal ion binding
Related Protein C1GALT1B; TFA; SP7; LMAN1; ZNF680; RNASEH2A; SDHB; ZNF367; GGPS1; ARSD
Function receptor activity
Related Protein RAMP1; LILRB2; CADM1; EXTL3; TNFRSF9; PAQR3A; NLGN4X; ROBO4; TNFRSF11B; ANTXR2
Function semaphorin receptor activity
Related Protein NRP2; NRP2B; PLXNB2B; NRP1B; PLXNC1; PLXNA1; PLXNA1B; NRP2A; NRP1A; PLXNA3
Function vascular endothelial growth factor-activated receptor activity
Related Protein PDGFRA; FLT1; NRP2; NRP2B; FLT3; NRP1B; NRP2A; NRP1; FLT4; NRP1A

NRP2 Related Articles

Gogineni, A; Caunt, M; et al. Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis. PLOS ONE 8:-(2013).
Susarla, R; Gonzalez, AM; et al. Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation. JOURNAL OF CELLULAR PHYSIOLOGY 227:1992-2002(2012).