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ONECUT2

Official Full Name

one cut homeobox 2
Overview

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.
Synonyms

ONECUT2; one cut homeobox 2; one cut domain, family member 2; one cut domain family member 2; OC 2; Transcription factor ONECUT 2; Transcription factor ONECUT2; HGNC:8139; MGC120377; MGC120378; OC2; ONECUT 2; ONECUT 2 homeodomain transcription factor; ONECUT 2 protein; ONECUT2 homeodomain transcription factor; ONECUT2 protein; HNF-6-beta; OTTHUMP00000216457; transcription factor ONECUT-2; hepatocyte nuclear factor 6-beta; ONECUT-2 homeodomain transcription factor; OC-2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ONECUT2-19HCL	Recombinant Human ONECUT2 HEK293T cell lysate	HEK293T	Myc/DDK		Inquiry
Human	ONECUT2-1459H	Recombinant Human ONECUT2, GST-tagged	E.coli	GST	226-332aa	$319 / 25ug
Human	ONECUT2-3539H	Recombinant Human ONECUT2 protein, His-tagged	E.coli	His	226-332 aa	$319 / 25ug
Mouse	ONECUT2-12154M	Recombinant Mouse ONECUT2 Protein	Mammalian Cell	His		Inquiry
Mouse	ONECUT2-6392M	Recombinant Mouse ONECUT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ONECUT2-6392M-B	Recombinant Mouse ONECUT2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
ONECUT2 Related Research Area

ONECUT2 involved in several pathways and played different roles in them. We selected most pathways ONECUT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ONECUT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ONECUT2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ONECUT2 itself. We selected most functions ONECUT2 had, and list some proteins which have the same functions with ONECUT2. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	ZNF543;NFKB2;SIX2;FOXJ2;RFX1A;CUX2;ZNF502;TFE3B;CTCFL
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	ATF2;IRF1;ESR1;PITX2;CEBPB;FOXI1;NEUROG3;FLI1;NR3C1

ONECUT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ONECUT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ONECUT2.

Hepatic Progenitor Cell Transcription Factors

Hepatic and Pancreatic Progenitor Cell Transcription Factors