osmr
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  • Official Full Name
  • oncostatin M receptor
  • Background
  • This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • OSMR; oncostatin M receptor; oncostatin-M-specific receptor subunit beta; OSMRB; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit; PLCA1
Cat.#:OSMR-454HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSMR Protein, MYC/DDK-tagged
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Cat.#:OSMR-1759HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSMR protein, His & T7-tagged
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Cat.#:OSMR-2318HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSMR, His tagged
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Cat.#:OSMR-542HTag:
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human OSMR
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Cat.#:Osmr-1016MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Osmr Protein, Fc Chimera
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Cat.#:Osmr-1760MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Osmr protein, His & GST-tagged
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Cat.#:Osmr-5187MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Osmr, His tagged
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Cat.#:Osmr-1761RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Osmr protein, His & T7-tagged
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Cat.#:OSMR-4209RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat OSMR Protein
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Cat.#:OSMR-2520HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSMR cell lysate
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Cat.#:OSMR-1789MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse OSMR cell lysate
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Involved Pathway

OSMR involved in several pathways and played different roles in them. We selected most pathways OSMR participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSMR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TGFB1A; CXCR3; CRFB2; IFNE; PRL2; CCL19B; LTBR; IFNAR1; FLT3; PDGFA
PIK-Akt signaling pathway
FGFR1; IL4R; LAMA1; RBL2; YWHAB; PDGFRB; ITGB4; EIF4E1B; KLK1B4; GNG11
Jak-STAT signaling pathway
IFNB; AOX3; IFNA13; IL4; PIM1; IL-15RA; PTPN2A; IL13; IL22RA2; LEPB

Protein Function

OSMR has several biochemical functions, for example, growth factor binding, contributes_to oncostatin-M receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OSMR itself. We selected most functions OSMR had, and list some proteins which have the same functions with OSMR. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor binding
Related Protein BMPR2; NKD2; REG3B; RPL37; HTRA1A; IGFBP2B; FGFBP2; NRP1; ERBB3; RHBDF2
Function contributes_to oncostatin-M receptor activity
Related Protein IL6ST; OSMR; LIFR

Interacting Protein

OSMR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSMR here. Most of them are supplied by our site. Hope this information will be useful for your research of OSMR.
ERBB2; GAPDH; q5nfj2_fratt; BAG3; Bmpr1a

OSMR Related Articles

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).