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PSME3

  • Official Full Name

    proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

  • Overview

    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.
  • Synonyms

    PSME3; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); proteasome activator complex subunit 3; Ki; PA28 gamma; PA28G; REG GAMMA; 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki antigen; Ki nuclear autoantigen; Ki, PA28 gamma; PA28gamma; Proteasome (prosome, macropain) activator subunit 3; Proteasome activator 28 gamma; Proteasome activator 28 subunit gamma; Proteasome activator subunit 3; PSME3_HUMAN; REG-gamma; proteasome activator 28-gamma; activator of multicatalytic prot; PA28-gamma;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PSME3-6860H Recombinant Human Proteasome (prosome, macropain) Activator Subunit 3 (PA28 gamma; Ki), His-tagged E.coli His 1-254aa
Human PSME3-2035H Recombinant Human PSME3, GST-tagged E.coli GST 1-254aa
Human PSME3-30434TH Recombinant Human PSME3, His-tagged E.coli His 254 amino acids
Human PSME3-359H Recombinant Human PSME3 protein, His-tagged E.coli His Met1-Tyr254
Human PSME3-2739HCL Recombinant Human PSME3 293 Cell Lysate HEK293 N/A
Human PSME3-2740HCL Recombinant Human PSME3 293 Cell Lysate HEK293 N/A
Human PSME3-1950H Recombinant Human PSME3 protein, His-tagged E.coli His Ala 2 - Tyr 254
Human PSME3-1977HFL Recombinant Full Length Human PSME3 Protein, C-Flag-tagged Mammalian cells Flag
Human PSME3-3384H Recombinant Human PSME3 protein, GST-tagged E.coli GST 2-252aa
Human PSME3-1785H Recombinant Human PSME3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PSME3-1785H-B Recombinant Human PSME3 Protein Pre-coupled Magnetic Beads HEK293
Mouse PSME3-13603M Recombinant Mouse PSME3 Protein Mammalian Cell His
Mouse Psme3-5203M Recombinant Mouse Psme3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PSME3-7228M-B Recombinant Mouse PSME3 Protein Pre-coupled Magnetic Beads HEK293
Mouse PSME3-7228M Recombinant Mouse PSME3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PSME3-827C Recombinant Cynomolgus PSME3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PSME3-570C-B Recombinant Cynomolgus Monkey PSME3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PSME3-570C Recombinant Cynomolgus Monkey PSME3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PSME3-8953Z Recombinant Zebrafish PSME3 Mammalian Cell His
Chicken PSME3-1923C Recombinant Chicken PSME3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PSME3 Related Research Area

PSME3 involved in several pathways and played different roles in them. We selected most pathways PSME3 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSME3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APC/C-mediated degradation of cell cycle proteinsUBE2C;ANAPC10;PSME3;PSMD10;PSMD14;PSMD9;PSMA8;CDK2;PSMD5
APC/C:Cdc20 mediated degradation of SecurinPSMD5;PSMD10;ANAPC10;PSME3;PSMA8;PSMD9;PSMD14;UBE2C
APC/C:Cdc20 mediated degradation of mitotic proteinsPSMA8;PSMD10;PSMD14;PSME3;UBE2C;PSMD9;NEK2;PSMD5;ANAPC10
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1PSMA8;PSMD14;PSMD10;PSMD5;AURKB;PSME3;ANAPC10;PSMD9;UBE2C
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointUBE2C;PSMA8;PSMD9;PSMD10;PSME3;PSMD14;NEK2;ANAPC10;PSMD5
ARMS-mediated activationMARK3;PAQR3A;PSMA8;KIDINS220B;PEBP1;DLG4;PSMD10;DUSP2;CSF2RA
AUF1 (hnRNP D0) binds and destabilizes mRNAPSMA8;PSMD5;PSMD9;EIF4G1;HNRNPD;PSMD14;PSME3;PSMD10
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsPSMD5;PSMD10;UBE2C;PSMD14;PSMA8;ANAPC10;NEK2;PSME3;PSMD9

PSME3 has several biochemical functions, for example, MDM2/MDM4 family protein binding, endopeptidase activator activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSME3 itself. We selected most functions PSME3 had, and list some proteins which have the same functions with PSME3. You can find most of the proteins on our site.

Function Related Protein
MDM2/MDM4 family protein bindingCAV1;PPARA;TRP53;RFWD3;PSME3;CDK5RAP3;CDKN2A
endopeptidase activator activityPSMD14;PSME2;ADRM1;SFRP2;PSME1;PSME3
identical protein bindingSOD1;PRKD1;APLP1;GUCY2E;MTPAP;SH3GLB1;ITGA2B;SERPINA1;TP53
p53 bindingNTRK3;SMYD2;EP300;SETD7;ZNF385A;HTT;EHMT2;MDM2;TAF1
protein bindingSHISA3;TMEM14C;TSEN2;Reln;BCAR3;OCLN;PVRL4;VTN;RRM1

PSME3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSME3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSME3.

ZCCHC10; EAF1; BBS2; MDM2

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