PAK6

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PAK6

Official Full Name p21 protein (Cdc42/Rac)-activated kinase 6
Background This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAK6-1284H Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 6, His-tagged Insect Cell His
    Human PAK6-19H Recombinant Human PAK6 E.coli N/A
    Human PAK6-32H Recombinant Human PAK6 protein, GST-tagged Wheat Germ GST
    Human PAK6-3454HCL Recombinant Human PAK6 293 Cell Lysate HEK293 N/A
    Human PAK6-381H Recombinant Human PAK6, GST-tagged, Active Sf9 Insect Cell GST
    Human PAK6-724H Recombinant Human PAK6, GST-His Sf9 Insect Cell GST
    Mouse PAK6-12322M Recombinant Mouse PAK6 Protein Mammalian Cell His
    Rhesus Macaque PAK6-3292R Recombinant Rhesus monkey PAK6 Protein, His-tagged Mammalian Cell His

    PAK6 involved in several pathways and played different roles in them. We selected most pathways PAK6 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PRKCG; MAP2K2A; SHC2; RAF1A; SOS1; SHC1; EREG; PRKCBB; RAF1; PAK6
    Ras signaling pathway PLA2G12A; RASAL2; PLA2G10; RAC2; PLA2G4D; ABL2; MAP2K1; GNG5; RAP1A; FGF3
    Axon guidance ROBO1; FES; CDK5R1B; SLIT3; ST8SIA2; AP2B1; GNAI2; TRIO; CSF2RB; AP2A2
    Focal adhesion COL24A1; PTK2AB; PDGFAB; PAK2A; ARHGAP5; LAMC3; MYL9; PDGFA; LAMA1; PARVAA
    T cell receptor signaling pathway CD3E; CD3D; PAK7; NCK2; PIK3CA; IL4; CD8B; PRKCQ; DLG1; MAP2K2; IKBKG
    Regulation of actin cytoskeleton EZRB; ITGA5; PIK3R2; FGF16; MOS; IQGAP3; TMSB4Y; ABI2A; FGF20B; ITGA1
    Renal cell carcinoma AKT2; FLCN; TGFB3; MAPK1; RAPGEF1; MAP2K2; HIF1A; KRAS; PDGFB; PIK3CB

    PAK6 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK6 itself. We selected most functions PAK6 had, and list some proteins which have the same functions with PAK6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SNRK; GM4922; ATP8B1; RUNX2; CDK15; KIF13B; HSP70; MAP4K6; SBK1; CCT6A
    Rac GTPase binding DVL1; PAK2B; SRGAP2B; PKN1; RCC2; RALBP1; PAK3; NOXA1; OCRL; CORO1C
    protein binding AIM2; ARMC8; GNL3L; WBP1L; CDC26; PPP1R15A; TAF1C; EED; FRG1; PDE2A
    protein serine/threonine kinase activity CLK3; STK39; AKT2L; TGFBR1; IRAK1; MAP2K3; PAK6; TNK2; BMPR1BA; CHEK2

    PAK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK6.

    LRRK2; RHOJ; PKM; LRRK1; HSP90AB1; YWHAQ; SNX2; CDK1; CDC42; SEMA3B; MAPK14; TPD52L1; NEK6

    Liu, WS; Liu, HO; et al. Prognostic Significance of p21-activated Kinase 6 Expression in Patients with Clear Cell Renal Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:S575-S583(2014).
    Zapatero, A; Morente, M; et al. Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1327-1332(2014).

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