pak6
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 6
  • Background
  • This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1
Cat.#:PAK6-381HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK6, GST-tagged, Active
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Cat.#:PAK6-724HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK6, GST-His
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Cat.#:PAK6-19HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK6
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Cat.#:PAK6-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PAK6 protein, GST-tagged
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Cat.#:PAK6-12322MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAK6 Protein
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Cat.#:PAK6-3292RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PAK6 Protein, His-tagged
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Cat.#:PAK6-1284HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 6, His-tagged
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Cat.#:PAK6-3454HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK6 293 Cell Lysate
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Involved Pathway

PAK6 involved in several pathways and played different roles in them. We selected most pathways PAK6 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAPK8; MAPK3; NRG2; MAPK9; GSK3AA; PLCG2; PRKCBB; NCK2; AREG; AREGB
Ras signaling pathway
STK4; FGF2; FGF10; INS1; PTPN11; FIGF; RGL1; PDGFC; PIK3CA; PIK3R1
Axon guidance
COL4A3; PPP3CB; RHOAE; CSNK2A1; SEMA3D; EFNA3; SLIT2; DNM2; KALRN; GNAI2
Focal adhesion
VEGFC; PRKCG; MYLK2; MAPK1; ITGB7; COL6A3; PDGFRB; COL6A5; SRMS; BAD
T cell receptor signaling pathway
IL4; PRKCQ; FYN; NFATC2; SLA1; LCP2; PDCD1; MAPK1; PIK3CG; SHB
Regulation of actin cytoskeleton
PIK3R3; PXNA; PPP1CBL; FGF12; ITGB3B; PIP4K2B; PAK2; Itga10&Itgb1; ITGAM; PFN4
Renal cell carcinoma
TCEB2; EPAS1; PIK3CB; AKT1; ETS1; RAP1A; EGLN1; TGFB3; ARAF; PAK3

Protein Function

PAK6 has several biochemical functions, for example, ATP binding, Rac GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK6 itself. We selected most functions PAK6 had, and list some proteins which have the same functions with PAK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CLP1; CDKL3; DSTYK; ABCG5; DNA2; UBE2Q2; SNRKB; ACSM1; CLK3; PDGFRA
Function Rac GTPase binding
Related Protein RAB7; ITPKA; SRGAP2A; PAK2; FLNA; DVL1; PAK2A; PAK6; SRGAP1; ARHGEF2
Function protein binding
Related Protein TBC1D7; IMPA2; SPPL2B; MYZAP; FPR1; KRT18; MAP3K13; C1orf189; RPS18; NPEPL1
Function protein serine/threonine kinase activity
Related Protein AURKB; NLK1; RPS6KA3; BSK146; MAP4K5; TLK2; CHEK2; STK30; GSK3B; RIOK3

Interacting Protein

PAK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK6.
LRRK2; RHOJ; PKM; LRRK1; HSP90AB1; YWHAQ; SNX2; CDK1; CDC42; SEMA3B; MAPK14; TPD52L1; NEK6

PAK6 Related Articles

Liu, WS; Liu, HO; et al. Prognostic Significance of p21-activated Kinase 6 Expression in Patients with Clear Cell Renal Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:S575-S583(2014).
Zapatero, A; Morente, M; et al. Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1327-1332(2014).