Recombinant Human PAK6 protein, GST-tagged

• Cat.No.: PAK6-32H
• Product Overview: Recombinant Human PAK6(1 a.a. - 681 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 101.3 kDa
• AA Sequence: MFRKKKKKRPEISAPQNFQHRVHTS FDPKEGKFVGLPPQWQNILDTLRRP KPVVDPSRITRVQLQPMKTVVRGSA MPVDGYISGLLNDIQKLSVISSNTL RGRSPTSRRRAQSLGLLGDEHWATD PDMYLQSPQSERTDPHGLYLSCNGG TPAGHKQMPWPEPQSPRVLPNGLAA KAQSLGPAEFQGASQRCLQLGACLQ SSPPGASPPTGTNRHGMKAAKHGSE EARPQSCLVGSATGRPGGEGSPSPK TRESSLKRRLFRSMFLSTAATAPPS SSKPGPPPQSKPNSSFRPPQKDNPP SLVAKAQSLPSDQPVGTFSPLTTSD TSSPQKSLRTAPATGQLPGRSSPAG SPRTWHAQISTSNLYLPQDPTVAKG ALAGEDTGVVTHEQFKAALRMVVDQ GDPRLLLDSYVKIGEGSTGIVCLAR EKHSGRQVAVKMMDLRKQQRRELLF NEVVIMRDYQHFNVVEMYKSYLVGE ELWVLMEFLQGGALTDIVSQVRLNE EQIATVCEAVLQALAYLHAQGVIHR DIKSDSILLTLDGRVKLSDFGFCAQ ISKDVPKRKSLVGTPYWMAPEVISR SLYATEVDIWSLGIMVIEMVDGEPP YFSDSPVQAMKRLRDSPPPKLKNSH KVSPVLRDFLERMLVRDPQERATAQ ELLDHPFLLQTGLPECLVPLIQLYR KQTSTC
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 [ Homo sapiens ]
• Official Symbol: PAK6
• Synonyms: PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; serine/threonine-protein kinase PAK 6; PAK5; PAK-5; PAK-6; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6
• Gene ID: 56924
• mRNA Refseq: NM_020168
• Protein Refseq: NP_064553
• MIM: 608110
• UniProt ID: Q9NQU5
• Chromosome Location: 15q14
• Pathway: Activation of Rac, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity