papss2
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  • Official Full Name
  • 3-phosphoadenosine 5-phosphosulfate synthase 2
  • Background
  • Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3-phosphoadenosine 5-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.
  • Synonyms
  • PAPSS2; 3-phosphoadenosine 5-phosphosulfate synthase 2; bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2; ATPSK2; SK 2; PAPSS 2; PAPS synthase 2; PAPS synthetase 2; ATP sulfurylase/APS kinase 2; ATP sulfurylase/adenosine 5-phosphosulfate kinase
Cat.#:PAPSS2-1524HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAPSS2, His-tagged
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Cat.#:PAPSS2-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAPSS2, His-tagged
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Cat.#:PAPSS2-3299RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PAPSS2 Protein, His-tagged
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Cat.#:PAPSS2-3440HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAPSS2 293 Cell Lysate
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Involved Pathway

PAPSS2 involved in several pathways and played different roles in them. We selected most pathways PAPSS2 participated on our site, such as Purine metabolism, Selenocompound metabolism, Sulfur metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPSS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PDE6D; ENTPD5; PDE4B; POLR3F; PRIM1; HDDC3; NPR1; PDE1B; POLR2B; PRUNE
Selenocompound metabolism
TXNRD1; SCLY; TRR1; CCBL2; PAPSS1; TXNRD3; SEPHS1; MTR; SEPSECS; PAPSS2A
Sulfur metabolism
SQRDL; TST; BPNT1; ETHE1; PAPSS2A; SUOX; PAPSS1; PAPSS2B; CYCS; MPST
Metabolic pathways
PFKL; POLR2L; HSD3B7; GGT5A; PIP5K1BB; CS; GGT1A; DGAT1A; ARG2; GLCEA

Protein Function

PAPSS2 has several biochemical functions, for example, ATP binding, adenylylsulfate kinase activity, nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPSS2 itself. We selected most functions PAPSS2 had, and list some proteins which have the same functions with PAPSS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDK7; ATP12A; ACSL5; NLRC3; DHX57; MYH1; INSRB; SCYL3; DGKAA; CLCN4-2
Function adenylylsulfate kinase activity
Related Protein PAPSS2A; PAPSS1; PAPSS2B; PAPSS2
Function nucleotidyltransferase activity
Related Protein POLE2; CMASB; OASL2; POLN; TERT; PRIM2; TAMM41; GMPPAA; GKUP; CTU2
Function sulfate adenylyltransferase (ATP) activity
Related Protein PAPSS1; PAPSS2; PAPSS2A; PAPSS2B

Interacting Protein

PAPSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPSS2.
VHL; Papss1

PAPSS2 Related Articles

Miccolis, A; Galluccio, M; et al. Significance of redox-active cysteines in human FAD synthase isoform 2. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:2086-2095(2014).
Iida, A; Simsek-Kiper, PO; et al. Clinical and Radiographic Features of the Autosomal Recessive form of Brachyolmia Caused by PAPSS2 Mutations. HUMAN MUTATION 34:1381-1386(2013).