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Official Full Name 3-phosphoadenosine 5-phosphosulfate synthase 2
Background Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3-phosphoadenosine 5-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Synonyms PAPSS2; 3-phosphoadenosine 5-phosphosulfate synthase 2; bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2; ATPSK2; SK 2; PAPSS 2; PAPS synthase 2; PAPS synthetase 2; ATP sulfurylase/APS kinase 2; ATP sulfurylase/adenosine 5-phosphosulfate kinase
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAPSS2-1524H Recombinant Human PAPSS2, His-tagged E.coli His
    Human PAPSS2-32H Recombinant Human PAPSS2, His-tagged E.coli His
    Human PAPSS2-3440HCL Recombinant Human PAPSS2 293 Cell Lysate HEK293 N/A
    Rhesus Macaque PAPSS2-3299R Recombinant Rhesus monkey PAPSS2 Protein, His-tagged Mammalian Cell His

    PAPSS2 involved in several pathways and played different roles in them. We selected most pathways PAPSS2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Selenocompound metabolism MARS2; TXNRD3; SPS2; PAPSS2A; TRR1; CCBL1; TXNRD2; SEPHS1; PAPSS2B; SEPSECS
    Sulfur metabolism ETHE1; PAPSS2; SUOX; IMPAD1; CYCS; cysH; PAPSS2B; TST; PAPSS1; CYCSB
    Metabolic pathways CHKB; PPAT; P4HA1A; NDUFB9; AUH; RPN2; BCKDHA; G6PDX; ATP6V1AA; ALAD

    PAPSS2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPSS2 itself. We selected most functions PAPSS2 had, and list some proteins which have the same functions with PAPSS2. You can find most of the proteins on our site.

    Function Related Protein
    adenylylsulfate kinase activity PAPSS2; PAPSS2B; PAPSS1; PAPSS2A
    nucleotidyltransferase activity GMPPAA; GMPPA; PAPSS1; CMASA; GMPPAB; CTU2; TERT; MOCS3; PRIM2; POLR3B
    sulfate adenylyltransferase (ATP) activity PAPSS1; PAPSS2A; PAPSS2; PAPSS2B

    PAPSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPSS2.

    VHL; Papss1

    Miccolis, A; Galluccio, M; et al. Significance of redox-active cysteines in human FAD synthase isoform 2. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:2086-2095(2014).
    Iida, A; Simsek-Kiper, PO; et al. Clinical and Radiographic Features of the Autosomal Recessive form of Brachyolmia Caused by PAPSS2 Mutations. HUMAN MUTATION 34:1381-1386(2013).

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