PAPSS2
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Official Full Name
3-phosphoadenosine 5-phosphosulfate synthase 2
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Overview
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3-phosphoadenosine 5-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. -
Synonyms
PAPSS2; 3-phosphoadenosine 5-phosphosulfate synthase 2; bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2; ATPSK2; SK 2; PAPSS 2; PAPS synthase 2; PAPS synthetase 2; ATP sulfurylase/APS kinase 2; ATP sulfurylase/adenosine 5-phosphosulfate kinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PAPSS2-32H | Recombinant Human PAPSS2, His-tagged | E.coli | His | ||
Human | PAPSS2-1524H | Recombinant Human PAPSS2, His-tagged | E.coli | His | 1-333aa | |
Human | PAPSS2-3440HCL | Recombinant Human PAPSS2 293 Cell Lysate | HEK293 | N/A | ||
Human | PAPSS2-5274H | Recombinant Human PAPSS2 Protein (Met1-Asn614), C-His tagged | Mammalian cells | C-His | Met1-Asn614 | |
Mouse | Papss2-4675M | Recombinant Mouse Papss2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rhesus Macaque | PAPSS2-3299R | Recombinant Rhesus monkey PAPSS2 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | PAPSS2-3117R-B | Recombinant Rhesus Macaque PAPSS2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | PAPSS2-3117R | Recombinant Rhesus Macaque PAPSS2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- PAPSS2 Related Articles
PAPSS2 involved in several pathways and played different roles in them. We selected most pathways PAPSS2 participated on our site, such as Purine metabolism, Selenocompound metabolism, Sulfur metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | NUDT5;UOX;PDE3A;ADSL;NT5C1B-RDH14;AK8;POLE4;PRPS1B;NT5C2 |
Selenocompound metabolism | MARS2;SPS2;PAPSS2A;SEPHS2;SEPHS1;SEPSECS;PSTK;TXNRD3;PAPSS1 |
Sulfur metabolism | CYCS;ETHE1;cysH;PAPSS2A;TST;PAPSS1;IMPAD1;PAPSS2B;SQRDL |
Metabolic pathways | MTHFD1B;CYP11B1;DHCR7;CHIA.4;GNPDA2;CYP21A1;ALDOB;ATP6V1BA;B3GNT5A |
PAPSS2 has several biochemical functions, for example, ATP binding, adenylylsulfate kinase activity, nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPSS2 itself. We selected most functions PAPSS2 had, and list some proteins which have the same functions with PAPSS2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CAMK2G1;MKKS;TAF1;NLRC4;ACLYA;UBE2Z;ABCB10;KIAA1804;RTCD1 |
adenylylsulfate kinase activity | PAPSS2A;PAPSS2B;PAPSS2;PAPSS1 |
nucleotidyltransferase activity | PAPSS2;POLN;GKUP;POLE2;TAMM41;TERT;GMPPAA;GDPGP1;REV3L |
sulfate adenylyltransferase (ATP) activity | PAPSS1;PAPSS2A;PAPSS2B;PAPSS2 |
PAPSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPSS2.
VHL; Papss1
- Q&As
- Reviews
Q&As (5)
Ask a questionInvestigations into PAPSS2 modulators are ongoing, and if identified, they could serve as potential therapeutic agents in clinical settings.
PAPSS2 is involved in sulfating hormones, impacting their activity. Mutations in PAPSS2 can lead to disorders like steroid sulfatase deficiency, affecting hormone metabolism.
PAPSS2 expression varies among tissues and developmental stages, reflecting its diverse roles in different physiological contexts.
Research exploring the therapeutic potential of targeting PAPSS2 is ongoing. It may offer new avenues for drug development in the future.
PAPSS2 is involved in sulfating sulfatide lipids, which are crucial for the integrity and function of cellular membranes.
Customer Reviews (3)
Write a reviewWhether investigating the role of PAPSS2 in angiogenesis, vascular development, or disease pathways, this protein surpasses expectations and guarantees reliable results.
The PAPSS2 protein is a superior-quality protein that perfectly aligns with my experimental requirements.
Its exceptional purity, consistency, and reliability make it an ideal choice for a wide range of research applications.
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