PARP4

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PARP4

Official Full Name poly (ADP-ribose) polymerase family, member 4
Background This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
Synonyms PARP4; poly (ADP-ribose) polymerase family, member 4; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 1 , ADPRTL1; poly [ADP-ribose] polymerase 4; p193; VAULT3; von Willebrand factor A domain containing 5C; VPARP; VWA5C; PARP-related; H5
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PARP4-156H Recombinant Human PARP4 protein, GST-tagged Wheat Germ GST
    Human PARP4-2162H Recombinant Human PARP4, His-tagged E.coli His
    Human PARP4-8198H Recombinant Human PARP4 protein, His & T7-tagged E.coli His/T7
    Chicken PARP4-4049C Recombinant Chicken PARP4 Mammalian Cell His

    PARP4 involved in several pathways and played different roles in them. We selected most pathways PARP4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base excision repair POLD2; TDG.1; PARP4; POLE4; XRCC1; APEX1; APEX2; POLD4; PCNA; LIG3

    PARP4 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP4 itself. We selected most functions PARP4 had, and list some proteins which have the same functions with PARP4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF84; ILF3; MB21D1; POU5F2; ZNF689; NFIB; DLX5A; HMG20B; LIG3; SMARCAD1
    NAD+ ADP-ribosyltransferase activity PARP16; PARP12; CHAT2; CHAT1; PARP6; PARP15; TNKS; GIG2Q; SIRT6; PARP12A
    enzyme binding PARK7; HMGA1; HNRNPUL1; DAOA; KMT2E; CDK19; HIST1H2AE; PPP1R3B; AXIN2; UGT1A1
    protein binding H2AFZ; ZCCHC8; FKBP8; RBBP4; CAV1; BRSK1; STK38; CSTF2; BBS4; GABBR1

    PARP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP4.

    ORF; brrf1_ebvg; CCT6A; SMAD3; purL; flgE; trpE; q81m31_bacan; q81uh3_bacan; cof4; fimD7; flgH2; q9wmx2-pro_0000037548; 2_aha_camp; CLTC; Lgals3bp; SNW1

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