PAX3

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PAX3

Official Full Name paired box 3
Background This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically;contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development.;Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and;alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead;gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding;isoforms with different C-termini.
Synonyms PAX3; paired box 3; paired box gene 3 (Waardenburg syndrome 1) , Waardenburg syndrome 1 , WS1; paired box protein Pax-3; HUP2; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3; WS1; WS3; CDHS; MGC120381; MGC120382; MGC120383; MGC
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAX3-1540H Recombinant Human PAX3, His-tagged E.coli His
    Human PAX3-29056TH Recombinant Human PAX3, GST-tagged Wheat Germ GST
    Human PAX3-3418HCL Recombinant Human PAX3 293 Cell Lysate HEK293 N/A
    Human PAX3-803H Recombinant Human PAX3 Mammalian Cell His
    Mouse PAX3-12392M Recombinant Mouse PAX3 Protein Mammalian Cell His
    Chicken PAX3-5842C Recombinant Chicken PAX3 Mammalian Cell His

    PAX3 involved in several pathways and played different roles in them. We selected most pathways PAX3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer HIST3H3; MLF1; HIST1H3A; PFTK1; KLF3; HOXA9; CLSTN2; TAF15; SFPI1; PTCRA

    PAX3 has several biochemical functions, for example, HMG box domain binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX3 itself. We selected most functions PAX3 had, and list some proteins which have the same functions with PAX3. You can find most of the proteins on our site.

    Function Related Protein
    HMG box domain binding HHEX; DLX5; JUN; GATA3; UTF1; PRRX1; HOXA3; PAX3; EGR2; CEBPA
    chromatin binding FANCM; ATOH1A; DMRT1; TOX4; CREBBP; TCF7; ARID5A; TRP63; KLF6A; TGIF1
    protein binding TSSK2; PLAC9; RMND5A; PDLIM4; ZFP110; MRPL49; ETV6; ELN; PRR13; CCDC25
    sequence-specific DNA binding CREBZF; FOXO1B; UBP1; HMX4; FOXK2; HOXD11A; POU3F2B; FOXQ1; SALL2; PPARAB
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding POU3F1; BHLHE40; CEBPB; NKX2; SFPI1; RFX3; SPI1; POU3F3; SOX7; FOXC2
    transcription factor activity, sequence-specific DNA binding ZNF549; SLC12A9; TCF7L1A; SALL1; ZBTB11; KDM3A; AHRRB; ZFP354A; SCML2; SOX2

    PAX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX3.

    POU3F2; MEOX2; SOX10; ABL1; FYN; SRC; NCK1; GRB2

    Kang, Z; Yu, Y; et al. Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. ONCOGENE 33:5697-5705(2014).
    Buresi, A; Croll, RP; et al. Emergence of Sensory Structures in the Developing Epidermis in Sepia officinalis and Other Coleoid Cephalopods. JOURNAL OF COMPARATIVE NEUROLOGY 522:3004-3019(2014).

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