pax3
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  • Official Full Name
  • paired box 3
  • Background
  • This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically;contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development.;Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and;alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead;gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding;isoforms with different C-termini.
  • Synonyms
  • PAX3; paired box 3; paired box gene 3 (Waardenburg syndrome 1) , Waardenburg syndrome 1 , WS1; paired box protein Pax-3; HUP2; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3; WS1; WS3; CDHS; MGC120381; MGC120382; MGC120383; MGC
Cat.#:PAX3-1540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX3, His-tagged
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Cat.#:PAX3-29056THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PAX3, GST-tagged
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Cat.#:PAX3-803HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PAX3
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Cat.#:PAX3-12392MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAX3 Protein
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Cat.#:PAX3-5842CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAX3
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Cat.#:PAX3-3418HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAX3 293 Cell Lysate
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Involved Pathway

PAX3 involved in several pathways and played different roles in them. We selected most pathways PAX3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
H3F3C; EYA1; FLI1; IGF1; HIST2H3C1; LRP2BP; MMP9; SSX2; H3F3B; NFKB1

Protein Function

PAX3 has several biochemical functions, for example, HMG box domain binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX3 itself. We selected most functions PAX3 had, and list some proteins which have the same functions with PAX3. You can find most of the proteins on our site.
Function
Related Protein
Function HMG box domain binding
Related Protein HHEX; CEBPA; SP1; OLIG2; UTF1; ALX4; MEOX1; POU3F3; PAX3; HOXA3
Function chromatin binding
Related Protein TRIM37; MEOX1; PYGO2; SUV39H1; SIRT6; SP3; NFATC3; HIST2H3C1; ASH1L; PROP1
Function protein binding
Related Protein ZC3HAV1; PLCE1; C20orf195; ACAA1; PDIA2; ZNF18; CTAG1A; LBH; MOXD1; FANCA
Function sequence-specific DNA binding
Related Protein VSX1; IRX5; HOXB6B; HOXC8A; NR1D4A; MSXB; NR5A1B; HOXC1A; ZNF165; SIX4A
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein USF1; RFX1; HNF1B; BHLHE40; FOXP3; MEIS1; IRF8; SOX9; AHR; SFPI1
Function transcription factor activity, sequence-specific DNA binding
Related Protein KCNA3; HOXA6; NFE2L2A; NR1D4A; ZNF454; HNF1B; NR2F1; SCMH1; HNF1BA; RNF4

Interacting Protein

PAX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX3.
POU3F2; MEOX2; SOX10; ABL1; FYN; SRC; NCK1; GRB2

PAX3 Related Articles

Kang, Z; Yu, Y; et al. Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. ONCOGENE 33:5697-5705(2014).
Buresi, A; Croll, RP; et al. Emergence of Sensory Structures in the Developing Epidermis in Sepia officinalis and Other Coleoid Cephalopods. JOURNAL OF COMPARATIVE NEUROLOGY 522:3004-3019(2014).