pdcd6ip
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  • Official Full Name
  • programmed cell death 6 interacting protein
  • Background
  • This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
  • Synonyms
  • PDCD6IP; programmed cell death 6 interacting protein; AIP1; ALIX; HP95; DRIP4; programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; ALG-2-interacting protein X; dopamine receptor interacting protein 4; apoptosis-linked gene 2-interacting protein X;
Cat.#:PDCD6IP-1938HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD6IP, His-tagged
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Cat.#:PDCD6IP-27933THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD6IP, His-tagged
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Cat.#:PDCD6IP-6715HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD6IP protein, His & GST-tagged
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Cat.#:Pdcd6ip-6716MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdcd6ip protein, His & T7-tagged
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Cat.#:PDCD6IP-4321RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDCD6IP Protein
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Cat.#:PDCD6IP-2676CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDCD6IP
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Cat.#:PDCD6IP-12540ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDCD6IP
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Cat.#:PDCD6IP-3358HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDCD6IP 293 Cell Lysate
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Involved Pathway

PDCD6IP involved in several pathways and played different roles in them. We selected most pathways PDCD6IP participated on our site, such as Budding and maturation of HIV virion, Disease, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD6IP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Budding and maturation of HIV virion
CHMP4B; CHMP4C; VPS37A; PDCD6IP; gag; PPIA
Disease
TRIM24; RDBP; CDK9; EEF2; FGFR1OP; KPNA4; RLBP1; OPN1MW; PSIP1; COBRA1
Endocytosis
ARPC5; VPS26A; GIT2B; TGFBR1; RAB11FIP5; ARPC1A; RAB35B; CHMP2A; SH3GLB2A; ACAP2
HIV Infection
TCEB3; CDK9; PSIP1; SSRP1; RCC1; PPIAL4A; NPM1; NMT2; CHMP4C; AP1M2
HIV Life Cycle
VPS37A; ELL; PSTPIP2; RCC1; PDCD6IP; PSIP1; CHMP4B; NMT1; TCEB3; CHMP4C
Infectious disease
CCDC167; TAF1L; NMT2; CHMP4B; RCC1; VPS37A; CHMP4C; APOBEC3G; ANTXR2; ANTXR1
Late Phase of HIV Life Cycle
NMT2; TAF1L; RCC1; PDCD6IP
Uptake and actions of bacterial toxins
SYT2; ANTXR1; ANTXR2; PDCD6IP

Protein Function

PDCD6IP has several biochemical functions, for example, SH3 domain binding, calcium-dependent protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD6IP itself. We selected most functions PDCD6IP had, and list some proteins which have the same functions with PDCD6IP. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein ERRFI1; DTX1; LANCL1; AFAP1L2; FMNL3; EVLB; INPPL1; ADAM10; FMN1; MAPT
Function calcium-dependent protein binding
Related Protein DMBT1; CALM3; TSG101; C9orf9; SEC31A; SYT8; SYN1; VAMP2; PDCD6; NRXN1
Function protein binding
Related Protein DYNC1I1; HARS2; OPRM1; DNAJC19; GTF2F1; NLRP3; FAIM; PSMA2; TGFBRAP1; SORT1
Function protein homodimerization activity
Related Protein MYH9; AMBP; VAPB; BCL2A; GSTM2; TESC; GZMA; SLC11A1; PCYT1A; ADH5
Function proteinase activated receptor binding
Related Protein PDCD6IP; PHB; BICD1

Interacting Protein

PDCD6IP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD6IP here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD6IP.
PDCD6; HCK; CEP55; FYN

PDCD6IP Related Articles

Murrow, L; Malhotra, R; et al. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. NATURE CELL BIOLOGY 17:300-+(2015).
Liu, SG; Yuan, SH; et al. The programmed cell death 6 interacting protein insertion/deletion polymorphism is associated with non-small cell lung cancer risk in a Chinese Han population. TUMOR BIOLOGY 35:8679-8683(2014).