pde2a
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  • Official Full Name
  • PDE2A phosphodiesterase 2A, cGMP-stimulated
  • Background
  • Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE2 enzyme belongs to a family of PDEs able to hydrolyse both intracellular second messengers, cAMP and cGMP
  • Synonyms
  • PDE2A; phosphodiesterase 2A, cGMP-stimulated; cGMP-dependent 3,5-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; PDE2A1; PED2A4; cGSPDE; CGS-PDE
Cat.#:PDE2A -906HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE2A , His tagged
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Cat.#:PDE2A-29979THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PDE2A
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Cat.#:PDE2A-472HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE2A, GST-tagged, Active
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Cat.#:PDE2A-606HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PDE2A
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Cat.#:PDE2A-3347RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDE2A Protein, His-tagged
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Cat.#:PDE2A-591HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE2A cell lysate
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Cat.#:Kit-1832Tag:N/A
Source (Host):Species:
Product namePDE2A Assay Kit I
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Cat.#:Kit-1833Tag:N/A
Source (Host):Species:
Product namePDE2A Assay Kit II
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Involved Pathway

PDE2A involved in several pathways and played different roles in them. We selected most pathways PDE2A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GUCY1B3; PDE8B; PDE4A; PNP5A; POLR2J; ENTPD2A.1; PDE4B; TWISTNB; PFAS; PGM1
cGMP-PKG signaling pathway
GNAI1; LOC100328615; ATP1A2; NFATC1; ATP2A1; PPP1CA; MYH7; MYLK4; PLCB1; GTF2IRD1
Olfactory transduction
PRKG1; NCALD; GNG7; OR4D6; PDE1C; OR8K5; OLFR688; OR10A4; OR8A1; PDE2A
Aldosterone synthesis and secretion
KCNK3; CAMK1D; Adcy4; PLCB1; PRKCB; CAMK2D; PRKCA; PDE2A; NR4A1; CALM4
Morphine addiction
GNG13; OPRM1; PDE4B; GNAS; GNG8; GNG12; GNAI3; PDE7B; GNG7; GABRP

Protein Function

PDE2A has several biochemical functions, for example, TPR domain binding, cAMP binding, cGMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE2A itself. We selected most functions PDE2A had, and list some proteins which have the same functions with PDE2A. You can find most of the proteins on our site.
Function
Related Protein
Function TPR domain binding
Related Protein HSP90AB1; STUB1; RAB8B; PDE2A; HSP90AA1
Function cAMP binding
Related Protein PDE10A; PRKAR2B; BVES; POPDC2; RAPGEF3; PDE4B; CNMPD1; PDE11A; HCN4; PDE3A
Function cGMP binding
Related Protein PDE5A; PDE10A; CNGA4; PDE11A; CNGA1; CNGA5; PRKG1A; PDE6C; CNGA2; CNGA3
Function cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Related Protein PDE11A; PDE2A; USB1; TDP2B; PDE10A
Function calcium channel activity
Related Protein CACNA1BA; PKD2L2; TRPV2; RYR1; TRPC6A; TRPC2; CACFD1; TRPN1; CACNG8A; RYR2
Function cyclic-nucleotide phosphodiesterase activity
Related Protein PDE2A; USB1; PDE11A; TDP2B
Function drug binding
Related Protein PNP; PPARG; FABP1; FOLR2; NAMPT; GSTP2; CHRNB4; ADH1; TOP2A; DRD2
Function metal ion binding
Related Protein CXXC1A; ZNF324; MYOC; ZNF580; PDE6C; NRP1; ZFP410; TP73; PHF23B; MOBKL2A
Function protein binding
Related Protein SNX15; MST1; PCSK9; LIG4; TNIK; WASH1; IL12B; CREB3L3; TYROBP; RNF113A
Function protein homodimerization activity
Related Protein DLK2; P2RX7; CCBL1; CD2; IKBKG; ZFP652; SLC26A5; TDG; MAFA; DMRTC1B

Interacting Protein

PDE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE2A.
AIP; 3',5'-cyclic amp; metE; q7ard3_yerpe

PDE2A Related Articles

Suzuki, T; Ikari, K; et al. PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study. PLOS ONE 8:-(2013).
Chao, YC; Cheng, CJ; et al. Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate. BIOCHEMICAL JOURNAL 432:267-273(2010).