PDE4C

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PDE4C

Official Full Name phosphodiesterase 4C, cAMP-specific
Background The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms PDE4C; phosphodiesterase 4C, cAMP-specific; DPDE1, phosphodiesterase 4C, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E1); cAMP-specific 3,5-cyclic phosphodiesterase 4C; phosphodiesterase E1 dunce homolog (Drosophila); cAMP specific 3 5 cyclic phosphodiesterase 4C; DPDE 1; DPDE1; MGC126222; PDE 21; PDE 4C; PDE21; Phosphodiesterase 4C; Phosphodiesterase 4C cAMP specific; Phosphodiesterase E1 dunce homolog; Phosphodiesterase E1 dunce homolog Drosophila; Phosphodiesterase Type 4C; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Pde4c-470M Recombinant Mouse Pde4c Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PDE4C-1528H Recombinant Human PDE4C (Active), GST-tagged Sf9 Insect Cell GST
    Human PDE4C-1600H Recombinant Human PDE4C, GST-tagged E.coli GST
    Human PDE4C-30820TH Recombinant Human PDE4C N/A
    Human PDE4C-3351HCL Recombinant Human PDE4C 293 Cell Lysate HEK293 N/A
    Human PDE4C-477H Recombinant Human PDE4C, GST-tagged, Active Sf9 Insect Cell GST
    Mouse PDE4C-12555M Recombinant Mouse PDE4C Protein Mammalian Cell His
    Kit-1840 PDE4C Assay Kit N/A

    PDE4C involved in several pathways and played different roles in them. We selected most pathways PDE4C participated on our site, such as Purine metabolism, cAMP signaling pathway, Morphine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism POLR2A; POLR2C; PDE4D; URAH; PAICS; AK5; POLR1D; NME4; NME7; ENTPD1
    cAMP signaling pathway HTR1B; PDE4B; GNAS; GLP1R; GABBR2; GPR119; HCN4; CNGA3; ATP1A1; PIK3CA
    Morphine addiction PDE8A; GNG11; GABRA6; PDE4D; GNG3; PDE7A; GABRA2; GNG7; OPRM1; GNAI3

    PDE4C has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, drug binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4C itself. We selected most functions PDE4C had, and list some proteins which have the same functions with PDE4C. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activity PDE7A; USB1; PDE4B; PDE8B; PDE8A; PDE7B; PDE4D; PDE4A; TDP2B; PDE4C
    drug binding SLC6A4A; PPP3CB; GRIK1; PDXK; CYP2D6; CHRNB2; Alb; UGT1A7; CHRNB4; DHFR
    metal ion binding SMYD2; COL9A1; ZUFSP; TAF1B; EGLN1B; RREB1; ZNF791; POLD1; ZNF433; SMAD6
    protein binding TBX3; GPRASP1; DPM3; TPSAB1; UBE3C; HDAC6; STAC; ARHGEF38; RUVBL1; SLC7A1

    PDE4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4C here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4C.

    Surmiak, M; Kaczor, M; et al. EXPRESSION PROFILE OF PROINFLAMMATORY GENES IN NEUTROPHIL-ENRICHED GRANULOCYTES STIMULATED WITH NATIVE ANTI-PR3 AUTOANTIBODIES. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 63:249-256(2012).
    Curatola, AM; Xu, J; et al. Cyclic GMP protects endothelial progenitors from oxidative stress. ANGIOGENESIS 14:267-279(2011).

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