pdia3
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  • Official Full Name
  • protein disulfide isomerase family A, member 3
  • Background
  • This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PDIA3; protein disulfide isomerase family A, member 3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n; protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n;
Cat.#:PDIA3-1841HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Disulfide Isomerase, His-tagged
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Cat.#:PDIA3-120HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDIA3, His-tagged
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Cat.#:PDIA3-1615HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDIA3, GST-tagged
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Cat.#:PDIA3-186HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDIA3 Protein, His-tagged
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Cat.#:PDIA3-20HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDIA3 protein, His-tagged
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Cat.#:PDIA3-26230THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDIA3, His-tagged
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Cat.#:PDIA3-12577MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDIA3 Protein
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Cat.#:PDIA3-4344RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDIA3 Protein
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Cat.#:PDIA3-3358RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDIA3 Protein, His-tagged
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Cat.#:PDIA3-5686CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDIA3
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Cat.#:PDIA3-7874ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDIA3
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Cat.#:PDIA3-3331HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDIA3 293 Cell Lysate
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Involved Pathway

PDIA3 involved in several pathways and played different roles in them. We selected most pathways PDIA3 participated on our site, such as Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDIA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
DNAJC3; CAPN2B; DNAJB1A; BCAP31; HSPBP1; UBQLNL; RAD23B; EIF2S1B; LMAN2; SYVN1
Antigen processing and presentation
NFYA; LGMN; CD74; B2M; HSPA5; KLRC4; CD8A; HSP90AA1; H2-AA; H2-Q10

Protein Function

PDIA3 has several biochemical functions, for example, cysteine-type endopeptidase activity, disulfide oxidoreductase activity, phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDIA3 itself. We selected most functions PDIA3 had, and list some proteins which have the same functions with PDIA3. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein USP47; MALT1; CTSO; USP22; BLMH; CASP9; CASPB; CTSB; CTSSB.2; CASP1
Function disulfide oxidoreductase activity
Related Protein TXN; DNAJC10; TXNL1; TMX1; PDIA3; COIL; GRX2; PDIA2
Function phospholipase C activity
Related Protein PLCB3; ADORA1; PLCG2; PDIA3; PLCG1; PLCL1; PLCB4; PLCH2; PLCB2; PLCE1
Function poly(A) RNA binding
Related Protein APOBEC3F; RBM19; NOSIP; PKM; RPUSD4; SRSF5; GPATCH8; FAM120A; SF3A2; EEF1A1
Function protein binding
Related Protein ADCK5; BBS7; FANCD2; PRCC; CAMK2B; SMN1; PLK2; FLI1; LRP12; KRTAP10-9
Function protein disulfide isomerase activity
Related Protein PIGK; PDIA4; TXNDC5; PDIA5; PDIA3; QSOX2; TMX4; QSOX1; ZNF169; GLRX2

Interacting Protein

PDIA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDIA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDIA3.
ERO1L; CLU; STIM1; APP; TAP1; env; Edem3; AGRN

PDIA3 Related Articles

Doroudi, M; Schwartz, Z; et al. Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A(2) activating protein and Ca2+/calmodulin-dependent protein kinase II. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 147:81-84(2015).
Nemere, I; Garbi, N; et al. The 1,25D(3)-MARRS Receptor/PDIA3/ERp57 and Lifespan. JOURNAL OF CELLULAR BIOCHEMISTRY 116:380-385(2015).