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Official Full Name proenkephalin
Background Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Synonyms Leu-enkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Met-enkephalin-Arg-Phe; Methionine enkephalin; OGF; Opioid growth factor; PENK; PENK(114-133); PENK(143-183); PENK(237-258); PENK_HUMAN; PPA; Proenkephalin A; Proenkephalin; Proenkephalin-A; Synenkephalin; Met Enkephalin
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PENK-2338H Recombinant Human PENK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PENK-3226H Recombinant Human PENK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Penk-4793M Recombinant Mouse Penk Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PENK-177H Recombinant Human PENK, His-tagged HEK293 His
    Human PENK-3298HCL Recombinant Human PENK 293 Cell Lysate HEK293 N/A
    Human PENK-8008H Recombinant Human PENK protein, His & T7-tagged E.coli His/T7
    Mouse PENK-12632M Recombinant Mouse PENK Protein Mammalian Cell His
    Rat PENK-4375R Recombinant Rat PENK Protein Mammalian Cell His

    PENK involved in several pathways and played different roles in them. We selected most pathways PENK participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PENK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors) PTGDR2; PROK1; RLN3; ADRB1; LPAR2B; SST; GPR37B; LTB4R; CYSLTR1; NMBB
    G alpha (i) signalling events PNOCB; CHRM2; FPR-RS4; RGS14; CNR1; ANXA1; POMCB; APPA; OPN1MW; S1PR1
    GPCR downstream signaling RGS11; FGD4; CALCRL; GPR132; SSTR4; RAMP3; OXGR1A.2; OPN4B; RHOAE; TAC2
    GPCR ligand binding CHRM4; FZD10; PENKA; NMBB; SETD6; CCBP2; OXER1; FPR-RS6; CALCRL; TAAR1
    Peptide ligand-binding receptors EDN3; PROK1; NMBA; QRFP; NMBB; CCL35.2; PRLH; KEL; CCL27; PPY
    Signal Transduction RNF41; OTULINB; AATF; OTUD7B; SKI; ARHGEF18; NMB; PTHLH; FMNL3; RIT1

    PENK has several biochemical functions, for example, neuropeptide hormone activity, opioid peptide activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PENK itself. We selected most functions PENK had, and list some proteins which have the same functions with PENK. You can find most of the proteins on our site.

    Function Related Protein
    neuropeptide hormone activity PYYA; PRLH; AVP; POMCA; CCK; NPFFL; PYY; GRP; AGRP; CORT
    opioid peptide activity PNOC; ZFP106; PENK; PDYN; CDC42EP2
    protein binding NCOA5; EYA2; RAB24; HSD17B10; SNRPN; DDX11; PAK6; PARP16; DOK6; PPM1A

    PENK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PENK here. Most of them are supplied by our site. Hope this information will be useful for your research of PENK.


    Subiran, N; Candenas, L; et al. Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide. FERTILITY AND STERILITY 98:617-U382(2012).
    Hanrieder, J; Ljungdahl, A; et al. L-DOPA-induced Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).

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