|Official Full Name||proenkephalin|
|Background||Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.|
|Synonyms||Leu-enkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Met-enkephalin-Arg-Phe; Methionine enkephalin; OGF; Opioid growth factor; PENK; PENK(114-133); PENK(143-183); PENK(237-258); PENK_HUMAN; PPA; Proenkephalin A; Proenkephalin; Proenkephalin-A; Synenkephalin; Met Enkephalin|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PENK involved in several pathways and played different roles in them. We selected most pathways PENK participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PENK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Class A/1 (Rhodopsin-like receptors)||PTGDR2; PROK1; RLN3; ADRB1; LPAR2B; SST; GPR37B; LTB4R; CYSLTR1; NMBB|
|G alpha (i) signalling events||PNOCB; CHRM2; FPR-RS4; RGS14; CNR1; ANXA1; POMCB; APPA; OPN1MW; S1PR1|
|GPCR downstream signaling||RGS11; FGD4; CALCRL; GPR132; SSTR4; RAMP3; OXGR1A.2; OPN4B; RHOAE; TAC2|
|GPCR ligand binding||CHRM4; FZD10; PENKA; NMBB; SETD6; CCBP2; OXER1; FPR-RS6; CALCRL; TAAR1|
|Peptide ligand-binding receptors||EDN3; PROK1; NMBA; QRFP; NMBB; CCL35.2; PRLH; KEL; CCL27; PPY|
|Signal Transduction||RNF41; OTULINB; AATF; OTUD7B; SKI; ARHGEF18; NMB; PTHLH; FMNL3; RIT1|
|Signaling by GPCR||PENKB; EMR2; PNOC; TRH; PNOCB; RGS21; ARHGEF18; UTS2; PPY; RGS6|
PENK has several biochemical functions, for example, neuropeptide hormone activity, opioid peptide activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PENK itself. We selected most functions PENK had, and list some proteins which have the same functions with PENK. You can find most of the proteins on our site.
|neuropeptide hormone activity||PYYA; PRLH; AVP; POMCA; CCK; NPFFL; PYY; GRP; AGRP; CORT|
|opioid peptide activity||PNOC; ZFP106; PENK; PDYN; CDC42EP2|
|protein binding||NCOA5; EYA2; RAB24; HSD17B10; SNRPN; DDX11; PAK6; PARP16; DOK6; PPM1A|
PENK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PENK here. Most of them are supplied by our site. Hope this information will be useful for your research of PENK.