pfdn6
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  • Official Full Name
  • prefoldin subunit 6
  • Background
  • PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and;beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin;containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 (PubMed 10209023)).
  • Synonyms
  • PFDN6; prefoldin subunit 6; HKE2, HLA class II region expressed gene KE2 , prefoldin 6; H2 KE2; KE 2; PFD6; H2KE2; HKE2; HLA class II region expressed gene KE2; KE2; KE2 protein; PFD6_HUMAN; Protein Ke2; prefoldin 6; KE-2; H2-KE2
Cat.#:PFDN6-4829HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PFDN6 Protein, GST-tagged
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Cat.#:PFDN6-1656HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFDN6, GST-tagged
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Cat.#:PFDN6-26966THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFDN6, His-tagged
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Cat.#:PFDN6-3407HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prefoldin Subunit 6, His-tagged
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Cat.#:PFDN6-3383RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PFDN6 Protein, His-tagged
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Cat.#:PFDN6-10806ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PFDN6
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Cat.#:PFDN6-3277HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PFDN6 293 Cell Lysate
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Involved Pathway

PFDN6 involved in several pathways and played different roles in them. We selected most pathways PFDN6 participated on our site, such as Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chaperonin-mediated protein folding
CCT8; TUBB4B; PFDN1; KIFC3; FKBP9; CCT2; FBXW4; FBXL5; PFDN6; CCT6A
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
CCT8; PFDN4; CCT7; PFDN5; PFDN1; CCT6A; TUBB4B; CCT5; TUBB4A; PFDN6
Metabolism of proteins
TIMM13; TIMM21; B3GALTL; TOMM40; PHC2; MUCL1; EIF2B1; SEMG1; IGFBP1A; LTF
Prefoldin mediated transfer of substrate to CCT/TriC
PFDN6; PFDN1; PFDN5; PFDN2; CCT6A; PFDN4; VBP1; CCT7
Protein folding
FKBP9; PFDN6; FBXW9; TBCD; CCT6A; FBXW4; NOP56; KIFC3; PFDN1; FBXW5

Protein Function

PFDN6 has several biochemical functions, for example, chaperone binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN6 itself. We selected most functions PFDN6 had, and list some proteins which have the same functions with PFDN6. You can find most of the proteins on our site.
Function
Related Protein
Function chaperone binding
Related Protein AHSA1; DNAJA4; FGB; C1orf182; GET4; CDC37; VWF; CDKN1B; UBL4A; HES1
Function unfolded protein binding
Related Protein CALRL2; SRSF12; GRPEL2; DNAJB11; CCT3; PFDN4; CCT6B; SSUH2RS1; HSPD1; RP2

Interacting Protein

PFDN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN6.
PRPF4; Tubb4b; MDM2; TUBA3E; MAP3K3; WRAP73; SPATA2; B4GALT2; Pfdn2; PPP6R2; POLR1A; PPP1CC; Ruvbl1; Vbp1; PPP2CB; MAPK7; HDAC1; Isy1; Wdr61; POLR3E