Recombinant Human Prefoldin Subunit 6, His-tagged

• Cat.No.: PFDN6-3407H
• Product Overview: Recombinant human PFDN6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: PFDN6-3407H
• Description: PFDN6, also known as HKE2 or PFD6, is a subunit of the heteromeric prefoldin complex that chaperones nascent actin and alpha- and beta-tubulin chains pending their transfer to the cytosolic chaperonin containing TCP1 (CCT) complex. It binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it and bind to nascent polypeptide chain and promote folding in an environment in which there are many competing pathways for nonnative proteins.
• Source: E.coli.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol.
• Molecular Weight: 16.7 kDa (149aa) confirmed by MALDI-TOF.
• Purity: > 95% by SDS - PAGE.
• Concentration: 0.5 mg/ml (determined by BCA assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKL E AQLTEN NIVKEELALL DGSNVVFKLL GPVLVKQELG EARATVGKRL DYIT AEIK RY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQA AKAGAPGKA.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Metabolism of proteins

Gene Information

• Gene Name: PFDN6 prefoldin subunit 6 [ Homo sapiens ]
• Synonyms: prefoldin subunit 6; HKE2; KE-2; PFD6; H2-KE2; MGC70744; PFDN6;prefoldin subunit 6; KE2 protein; prefoldin 6; protein Ke2; OTTHUMP00000029360; OTTHUMP00000178657; HLA class II region expressed gene KE2; Protein Ke2
• Gene ID: 10471
• mRNA Refseq: NM_001185181
• Protein Refseq: NP_001172110
• MIM: 605660
• UniProt ID: O15212
• Chromosome Location: 6p21.3
• Function: chaperone binding; protein binding; unfolded protein binding