PHLPP2
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Official Full Name
PH domain and leucine rich repeat protein phosphatase 2 -
Overview
PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through -
Synonyms
PHLPP2;PH domain and leucine rich repeat protein phosphatase 2;PH domain and leucine rich repeat protein phosphatase like , PHLPPL;PH domain leucine-rich repeat-containing protein phosphatase 2;KIAA0931;PH domain leucine rich repeat protein phosphatase like;PHLPP like;PHLPPL
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
- Flag
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHLPP2-1615 | Recombinant Human PHLPP2 protein, GST-tagged | E.coli | Human | GST | 766-1043 |
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| PHLPP2-1615H | Recombinant Human PHLPP2, GST-tagged | E.coli | Human | GST | 766-1043 |
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| PHLPP2-1690H | Recombinant Human PHLPP2, His-tagged | E.coli | Human | His | 575-781aa |
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| PHLPP2-5880Z | Recombinant Zebrafish PHLPP2 | Mammalian Cells | Zebrafish | His |
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| PHLPP2-7012H | Recombinant Human PHLPP2, GST-tagged | E.coli | Human | GST | 766-1043 aa |
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| PHLPP2-1670H | Recombinant Human PHLPP2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| PHLPP2-1670H-B | Recombinant Human PHLPP2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PHLPP2-1843HFL | Recombinant Full Length Human PHLPP2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| PHLPP2-2720H | Recombinant Human PHLPP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Phlpp2-4843M | Recombinant Mouse Phlpp2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
PHLPP2 involved in several pathways and played different roles in them. We selected most pathways PHLPP2 participated on our site, such as PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHLPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | Il4ra,GNG4,PPP2R3A,PKN2,MDM2,PRKCA,PDGFB,G6PC2,PDGFRA,MCL1 |
Protein Function
PHLPP2 has several biochemical functions, for example, metal ion binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHLPP2 itself. We selected most functions PHLPP2 had, and list some proteins which have the same functions with PHLPP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | PPM1H,PP2D1,TAB1,MTMR6,PPM1BB,CDC14AA,PDP2,MTMR3,PPM1F,PPM1A |
| metal ion binding | NTHL1,RNF216,CA14,NEK7,FBXO5,ADAL,ZNF26,ZNF136,FXC1,GUCA1E |
Interacting Protein
PHLPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHLPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHLPP2.
PRKCB;SLC9A3R1;PHLPP1;USP12;USP1;EZR;RDX;USP46;SLC9A3R2;Scrib;WDR48;WDR20;SNX27;VAT1;RPS6KB1
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