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PI4KA

Official Full Name

phosphatidylinositol 4-kinase, catalytic, alpha
Overview

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.
Synonyms

PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha; PIK4CA; phosphatidylinositol 4-kinase alpha; PI4K ALPHA; pi4K230; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase, type III, alpha; PI4K-ALPH;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Rat

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Sf21
Sf9 Insect Cell
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PI4KA-161H	Active Recombinant Human PI4KA protein, GST-tagged	Insect Cell	GST		$698 / 5ug
Human	PI4KA-143HFL	Active Recombinant Full Length Human PI4KA Protein, N-Flag-tagged	Sf21	Flag	Full Length	Inquiry
Human	PI4KA-30331TH	Recombinant Human PI4KA	Wheat Germ	N/A	110 amino acids	Inquiry
Human	PI4KA-1700H	Recombinant Human PI4KA, His-tagged	E.coli	His	C-term-300aa	$319 / 25ug
Human	PI4KA-117H	Recombinant Human PI4KA, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	PI4KA-3207HCL	Recombinant Human PI4KA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PI4KA-4905H	Recombinant Human PI4KA Protein (Met1-Tyr300), N-GST tagged	E.coli	N-GST	Met1-Tyr300	Inquiry
Human	PI4KA-1701H	Recombinant Human PI4KA protein, His-GST-tagged	E.coli	His/GST	Met1~Trp300	Inquiry
Rat	PI4KA-4439R	Recombinant Rat PI4KA Protein	Mammalian Cell	His		Inquiry
Rat	PI4KA-4099R	Recombinant Rat PI4KA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PI4KA-4099R-B	Recombinant Rat PI4KA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PI4KA involved in several pathways and played different roles in them. We selected most pathways PI4KA participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4KA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Inositol phosphate metabolism	PIK3C2G;PIP5K2;MTMR7;MTMR1A;PLCB2;PI4KAA;MTMR7A;PIP5K1B;MTMR4
Metabolic pathways	P4HA2;Atp5g2;CYP11C1;ITGB1BP3;GLUD1A;PNLIPRP2;MINPP1A;PAFAH2;RDH10
Phosphatidylinositol signaling system	CALM4;ITPK1A;PLCB3;PTEN;PIP5K1A;PIKFYVE;PI4K2B;PIP5K1BA;CALM2B

PI4KA has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity, ATP binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4KA itself. We selected most functions PI4KA had, and list some proteins which have the same functions with PI4KA. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol 4-kinase activity	PI4KAB;PI4KAA;PI4K2A;PI4K2B;PI4KA;PI4KB
ATP binding	PAPSS1;UBE2QL1;TAF1;FER;KIFC2;UBE2KB;RFC5;ERCC6;ADCY8
protein binding	KLRB1B;Fert2;HEATR5B;RBM39;JUNB;GJB6;C19orf73;ITGB3B;PTPRN

PI4KA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4KA here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4KA.

q99ib8-pro_0000045602; p27958-pro_0000037576; VCAM1; q9wmx2-pro_0000037551; TNNT1; purL; dnaJ2