pik3c2a
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  • Official Full Name
  • phosphoinositide-3-kinase, class 2, alpha polypeptide
  • Background
  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
  • Synonyms
  • PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K C2alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha
Cat.#:PIK3C2A-163HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3C2A protein, GST-tagged, Active
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Cat.#:PIK3C2A-1715HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3C2A, His-tagged
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Cat.#:PIK3C2A-551HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3C2A Protein, His-tagged
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Cat.#:Pik3c2a-552MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pik3c2a Protein, His/GST-tagged
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Cat.#:PIK3C2A-1452HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3C2A (Active), GST-tagged
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Cat.#:PIK3C2A-3191HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3C2A 293 Cell Lysate
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Involved Pathway

PIK3C2A involved in several pathways and played different roles in them. We selected most pathways PIK3C2A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
INPP5E; PI4KAA; INPP4A; ITPKB; SYNJ2; IMPA2; MTMR8; ALDH6A1; PLCH2; PLCD1B
Metabolic pathways
CYP2J6; BAAT; SDHC; AMY2A2; IDH3B; PAPSS2; GCH2; ALDH1A1; CYP7A1; ATP6V1F
Phosphatidylinositol signaling system
CALM3B; PIK3R1; MTMR4; PLCD1A; PRKCB; INPP4AB; MTMR8; TMEM55B; INPP5L; CALM

Protein Function

PIK3C2A has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2A itself. We selected most functions PIK3C2A had, and list some proteins which have the same functions with PIK3C2A. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3C2G; PIK3CB; PIK3CD; PIK3C2B; PIK3CA; PIK3C2A; ATM; PIK3CG; PIK3R3; PIK3C3
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2B; PIK3C2G; PIK3CB; PIK3C2A; PIK3CA; PIK3CG; PIK3CD
Function ATP binding
Related Protein UBE2E3; ACACB; OASL; CDK20; PSTK; PRKACBA; KIF18A; MARK2; Adcy4; ABCD1
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3C2A; PIK3CG; PIK3CA; PIK3CB; PIK3CD
Function phosphatidylinositol binding
Related Protein SNX22; PLD1; SNX7; SNX9B; NOXO1A; ARHGAP33; ING2; TULP2; SNX33; SNX12

Interacting Protein

PIK3C2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2A.
Dlg4; ATG7; STAMBP; PGK1; TARS; FKBP4; MAP1LC3A; ANKFY1; PA2G4; AMOT; phoA; purvalanol b; Sec24c; GAK; SEC16A; EGFR; ERBB2; CLTB; FLNA

PIK3C2A Related Articles

Muffak-Granero, K; Olmedo, C; et al. Gene Network Profiling Before and After Transplantation in Alcoholic Cirrhosis Liver Transplant Recipients. TRANSPLANTATION PROCEEDINGS 44:1493-1495(2012).
Huang, WS; Wang, TB; et al. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. WORLD JOURNAL OF GASTROENTEROLOGY 18:3458-3464(2012).