pik3c2b
Share
  • Official Full Name
  • phosphoinositide-3-kinase, class 2, beta polypeptide
  • Background
  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
  • Synonyms
  • PIK3C2B; phosphoinositide-3-kinase, class 2, beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; C2 PI3K; PI3K C2beta; PI3K-C2beta; PI3K-C2-beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta; phosphoi
Cat.#:PIK3C2B-118HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3C2B, GST-tagged
+Inquiry
Cat.#:PIK3C2B-164HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3C2B protein, GST-tagged, Active
+Inquiry
Cat.#:PIK3C2B-1716HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3C2B, His-tagged
+Inquiry
Cat.#:Pik3c2b-1722RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pik3c2b protein, His & T7-tagged
+Inquiry

Involved Pathway

PIK3C2B involved in several pathways and played different roles in them. We selected most pathways PIK3C2B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIP4K2B; PIK3C2B; PIK3C2A; PLCD1A; PIP5K2; INPP5B; IP6K3; PLCD1B; PI4KA; PIP5K1C
Metabolic pathways
POLR1B; CKMT2; COQ7; CBR1; GULO; ACAA2; ACLYA; HYAL1; POLR2GL; ALPI.2
Phosphatidylinositol signaling system
TMEM55B; PPIP5K2; DGKE; CALM2; PRKCBA; PLCG2; PI4KAA; PIP4K2AA; ITPR1; PRKCBB

Protein Function

PIK3C2B has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2B itself. We selected most functions PIK3C2B had, and list some proteins which have the same functions with PIK3C2B. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R3; PIK3CA; PIK3C2B; PIK3C2A; PIK3CB; PIK3CD; PIK3CG; PIK3C3; PIK3C2G; ATM
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2G; PIK3C2A; PIK3C2B; PIK3CG; PIK3CB; PIK3CD; PIK3CA
Function ATP binding
Related Protein EPHA2; NLK2; ENPP1; FGFR4; P2RX3A; CCC2; CKMA; ABCA4A; PRKCI; RAF1A
Function lipid kinase activity
Related Protein DGKZ; PIK3C2B; TAE1
Function phosphatidylinositol binding
Related Protein SNX33; SNX18B; NOXO1; AKR1C1; MTM1; SLC12A9; ITPR3; SNX19A; PIK3C2G; WDR35
Function protein binding
Related Protein E2F8; KLC1; MOV10; TRMT61B; WIBG; PDCL3; GLUD1; CACNA1SB; MAPRE3; FBP1

Interacting Protein

PIK3C2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2B.
EGFR; TRIM27; GRB2; ERBB2; PDGFRB; NCK1