PINK1 Protein, PTEN induced putative kinase 1

PINK1

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PINK1

Official Full Name PTEN induced putative kinase 1
Background PINK1 (PTEN-induced putative kinase 1) is a serine/threonine protein kinase that localises to mitochondria. It has been implicated in protecting cells from stress-induced mitochondrial dysfunction. Mutations in this gene are thought to be the cause of autosomal recessive early-onset Parkinson disease 6 (PARK6).
Synonyms PINK1; PTEN induced putative kinase 1; BRPK; PARK6; FLJ27236; Parkinson disease (autosomal recessive) 6; Serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; OTTHUMP00000002881; protein kinase BRPK
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • P. humanus
    • T. castaneum
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MBP&His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    T. castaneum PINK1-001T Recombinant T. castaneum PINK1 Protein, MBP/His-tagged E. coli MBP&His
    P. humanus PINK1-002P Recombinant P. humanus PINK1 Protein E. coli
    Human PINK1-1347H Recombinant Human PTEN Induced Putative Kinase 1 E.coli N/A
    Human PINK1-1352HCL Recombinant Human PINK1 cell lysate N/A
    Human PINK1-30963TH Recombinant Human PINK1 E.coli N/A
    Human PINK1-357H Recombinant Human PTEN Protein, His-tagged E. coli His
    Human PINK1-3902H Recombinant Human PINK1 Protein, GST-tagged Wheat Germ GST
    Human PINK1-3929HCL Recombinant Human PINK1 Cell Lysate HEK293 N/A
    Human PINK1-392H Recombinant Human PINK1 Protein, GST-tagged Insect cell GST
    Mouse PINK1-12820M Recombinant Mouse PINK1 Protein Mammalian Cell His
    Mouse Pink1-1804M Recombinant Mouse Pink1 protein, His & T7-tagged E.coli His/T7
    Cynomolgus Monkey PINK1-792C Recombinant Cynomolgus PINK1 Protein, His-tagged Mammalian Cell His
    Zebrafish PINK1-1917Z Recombinant Zebrafish PINK1 Mammalian Cell His

    PINK1 involved in several pathways and played different roles in them. We selected most pathways PINK1 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PINK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons disease UQCRB; SNCAIP; SNCA; NDUFV1; NDUFS7; PARK2; NDUFB8; NDUFS3; NDUFB11; VDAC2

    PINK1 has several biochemical functions, for example, ATP binding, C3HC4-type RING finger domain binding, calcium-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PINK1 itself. We selected most functions PINK1 had, and list some proteins which have the same functions with PINK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding C22orf28; PLK2B; TOR1L3; AK5; DYRK3; MAP3K14; ACTA1; PRKACG; CDK17; PSMC1
    C3HC4-type RING finger domain binding HSPA8; PINK1; HSPA1A; HSPA1B; DNAJA1; KCNH2
    calcium-dependent protein kinase activity PINK1
    kinase activity NEK5; MAP2K4A; PRKAR1AA; PRKACBA; TNIKB; PIP5K1AA; BMPR2B; PRKCDA; ADCK3; CDC7
    magnesium ion binding NIM1K; PGM3; MAST4; MTPAP; EYA2; PI4K2A; ALPI; FARSB; FEN1; PRPS1L1
    peptidase activator activity CLPX; PSME4B; PSME4; CAV1; MMP25; FBLN1; APP; PINK1; MMP14; FN1
    protease binding SRI; SERPINF2; FURIN; FAP; INS; TP53; INS2; OS9; INS1; CNTNAP2
    protein binding IL12A; GTF2IRD2; OAZ1; F3; FAM19A4; COL13A1; TECPR1; C2orf50; STAM; PPP1R7
    protein kinase B binding APPL1; TRAF6; BAD; PINK1; CCDC88A; PDE3B; CDC37; BCL10; ANKRD2; RARA
    protein kinase activity MAPK12B; NAT1; POMK; STK4; GRK7B; SNRKB; OXSR1B; EK1; SMOK2B; PRKD2
    protein serine/threonine kinase activity STK24; BSK146; MAST4; PIM3; ROCK2B; PHKG2; LATS2; HIPK2; CSNK1G2A; MAP3K11
    ubiquitin protein ligase binding MID1; CDC34B; TUBB; WASH1; LRPPRC; LC3; YOD1; PRR5L; CUL3B; TRP53

    PINK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PINK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PINK1.

    PARK2; EED; FBXO7

    Auburger, G; Gispert, S; et al. Mitochondrial Acetylation and Genetic Models of Parkinson's Disease. MITOCHONDRION IN AGING AND DISEASE 127:155-182(2014).
    Wood-Kaczmar, A; Deas, E; et al. The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson's Disease. SODIUM CALCIUM EXCHANGE: A GROWING SPECTRUM OF PATHOPHYSIOLOGICAL IMPLICATIONS 961:241-249(2013).

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