Recombinant Human PINK1 Protein, GST-tagged

• Cat.No.: PINK1-392H
• Product Overview: Recombinant human PINK1 (114-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: PTEN-induced kinase 1 (PINK1) is a serine/threonine protein kinase that was identified initially in cancer cells as a gene up-regulated by overexpression of the major tumor suppressor, PTEN. It localizes to mitochondria, and regulates multiple aspects of mitochondrial biology. It is implicated in ubiquitin-dependent protein catabolic process to clear damaged mitochondria through selective autophagy (mitophagy). Mutations in the PINK1 gene are linked to early-onset recessive Parkinson disease.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Molecular Mass: 78 kDa
• Purity: >70%
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Gene Information

• Gene Name: PINK1 PTEN induced putative kinase 1 [ Homo sapiens ]
• Official Symbol: PINK1
• Synonyms: PINK1; PTEN induced putative kinase 1; PARK6, Parkinson disease (autosomal recessive) 6; serine/threonine-protein kinase PINK1, mitochondrial; protein kinase BRPK; PTEN-induced putative kinase protein 1; BRPK; PARK6; FLJ27236
• Gene ID: 65018
• mRNA Refseq: NM_032409
• Protein Refseq: NP_115785
• MIM: 608309
• UniProt ID: Q9BXM7