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Official Full Name protein kinase N1
Background The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kina
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PKN1-1289H Recombinant Human Protein Kinase N1, GST-tagged Insect Cell GST
    Human PKN1-1363HCL Recombinant Human PKN1 cell lysate N/A
    Human PKN1-1744H Recombinant Human PKN1, His-tagged E.coli His
    Human PKN1-2709H Recombinant Human PKN1 protein, His & T7-tagged E.coli His/T7
    Human PKN1-704H Recombinant Human Protein Kinase N1, GST-His Sf9 Insect Cell GST
    Human PKN1-72H Recombinant Human PKN1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse PKN1-12873M Recombinant Mouse PKN1 Protein Mammalian Cell His
    Rat PKN1-4482R Recombinant Rat PKN1 Protein Mammalian Cell His

    PKN1 involved in several pathways and played different roles in them. We selected most pathways PKN1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway ITGA7; FGF2; MAP2K1; COL6A5; MAP2K2; EPOR; PDGFC; PPP2R5D; TLR4; LAMB4
    Salmonella infection KLC1; MAPK8; ARPC5LA; RHOGD; CCL4; ROCK2B; PFN2L; PKN1; ARPC5B; ACTG1

    PKN1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PKN1 itself. We selected most functions PKN1 had, and list some proteins which have the same functions with PKN1. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding CDKL5; CAV1; PAK6; ARHGAP4A; SRGAP1; PAK4; SRGAP2; PAK2; NOX1; FMNL1
    androgen receptor binding TRIM68; NCOA1; RAN; RB1; GRIP1; KDM1A; TGFB1I1; PIAS2; NSD1; Ar
    chromatin binding HMGB1; TOX3; ZFP354B; MBD5; PRMT6; MSL1A; TLE1; ARID3C; DNMT3B; ATRX
    histone binding L3MBTL2; DAXX; APBB1; UIMC1; HIST1H4N; CTCFL; SET; L3MBTL1; TONSL; HIST1H3I
    histone deacetylase binding D7ERTD443E; NR2C1; TOP2A; BRMS1; MAGEA2B; ZNF703; RAD9A; ZFP932; ZMYND15; YWHAE
    histone kinase activity (H3-T11 specific) CHEK1; PKN1
    ligand-dependent nuclear receptor transcription coactivator activity ATXN7L3; DCAF6; PPARGC1B; AASS; ACTN1; TADA3; MED24; SFR1; PKN1; MED30
    protein binding UPF1; EPHA3; EDARADD; GABARAPL2; DPM1; NR1H3; PSMC5; C16orf45; CCL28; RECQL
    protein kinase C activity PRKCHA; PRKCG; PKN2; PRKCI; PRKCB; PKN1; PRKD1; PRKD2; PRKCH; PRKCD
    protein kinase C binding GLRX3; PRKCB; HDAC5; FLNA; HDAC9; ADAM9; PLEK; TOP2A; PARD3; DACT1
    protein kinase activity PDPK1A; PDK3; NPRL2; KALRN; CDK5R1; WNK2; FGFR1A; STK24B; MAP4K3; RPS6KAL
    protein serine/threonine kinase activity ADCK2; MARK1; STK36; CDC42BPB; MAPK8; PRKCB; PAK7; MAPK12; GSK3B; SGK2B

    PKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKN1.


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