pkn1
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  • Official Full Name
  • protein kinase N1
  • Background
  • The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kina
Cat.#:PKN1-1744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PKN1, His-tagged
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Cat.#:PKN1-2709HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PKN1 protein, His & T7-tagged
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Cat.#:PKN1-704HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase N1, GST-His
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Cat.#:PKN1-72HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PKN1 protein, Flag-tagged, Biotinylated
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Cat.#:PKN1-12873MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PKN1 Protein
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Cat.#:PKN1-4482RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PKN1 Protein
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Cat.#:PKN1-1289HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Protein Kinase N1, GST-tagged
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Cat.#:PKN1-1363HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PKN1 cell lysate
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Involved Pathway

PKN1 involved in several pathways and played different roles in them. We selected most pathways PKN1 participated on our site, such as PIK-Akt signaling pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
TLR2; IL2RA; IFNA12; FGF5; EIF4E1B; ITGA8; INS; PKN1; PDGFC; FN1
Salmonella infection
PYCARD; CASPA; RAB7A; NOS2A; IL18; FLNB; DYNC1I2A; FOS; ACTB1; TJP1

Protein Function

PKN1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKN1 itself. We selected most functions PKN1 had, and list some proteins which have the same functions with PKN1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACSM5; PKN2; PKDCCA; NAIP6; MKNK2; P2RX4B; PANK1; SMC1B; KCNJ8; SRX1
Function GTP-Rho binding
Related Protein EXOC1; CDC42EP1; CDC42EP5; RTKN; KCTD13; ROCK2B; CDC42EP4; TRIOBP; CDC42EP2; ROCK2A
Function Rac GTPase binding
Related Protein DVL1; ARHGEF2; PAK1; NOXA1; FMNL1; ITPKA; DOCK4; PAK2B; EPS8; PKN1
Function androgen receptor binding
Related Protein CDK7; NCOA4; FHL2; PARK7; DAXX; RNF4; TGFB1I1; NSD1; PRMT2; PIAS2
Function chromatin binding
Related Protein LHX2; HDAC7A; SATB1; POU5F3; URI1; ZFP354B; WAC; TMPOA; ARID5A; YBX1
Function histone binding
Related Protein CHD8; SERPINB1A; HIST2H4A; SMARCA4A; NCL; PKN1; CHD2; BAZ2A; PYGO2; SUPT6H
Function histone deacetylase binding
Related Protein MAGEA1; CBX5; FOXP3; NKX3-1; BRMS1; NR2E1; TAL1; GMNN; HDAC9; BCOR
Function histone kinase activity (H3-T11 specific)
Related Protein PKN1; CHEK1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED14; SFR1; SRA1; ATXN7L3; SMARCD3; MED30; CCAR1; CARM1; DCAF6; CCDC62
Function protein binding
Related Protein GFAP; PPP1R9A; PRPF3; MICALL2; NSL1; TAF1B; IRS1; G6PD; PTGFRN; TBXA2R
Function protein kinase C activity
Related Protein PRKD3; PRKCQ; PRKCBB; PRKCH; PRKCZ; PRKCBA; PRKCG; PRKCHA; PRKCB; PRKD2
Function protein kinase C binding
Related Protein FEZ1; ADAM9; AKT1; SDPRA; SQSTM1; PDLIM5; PARD3; NELL2; TRPV4; PKP2
Function protein kinase activity
Related Protein SRPK1A; CSF1RA; GSK3AA; PAK2A; ERBB4A; PRPF4BB; GRK7A; DAPK2A; GUCY2C; EPHA4A
Function protein serine/threonine kinase activity
Related Protein TNK2; TAOK1; TRIOA; LATS1; RPS6KA5; PDK3; ULK1; MTOR; PBK; MAP4K6

Interacting Protein

PKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKN1.
HOMER3; MID1; VIM; KRT15; CDR2; GOLGA2; KRT31