PKN1
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Official Full Name
protein kinase N1
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Overview
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kina;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PKN1 involved in several pathways and played different roles in them. We selected most pathways PKN1 participated on our site, such as PIK-Akt signaling pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | TNR;IBSP;PPP2R5A;FGF17;PDPK1;CREB3L1;INS1;PIK3CG;LAMB1 |
| Salmonella infection | RAB7B;ACTB1;LBP;RAB7;DYNC2H1;ARPC5LB;IL18;PFN1;DYNC1I1 |
PKN1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKN1 itself. We selected most functions PKN1 had, and list some proteins which have the same functions with PKN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | THRAP3;DDX23;ACSM4;SMARCA2;RAD54L;STK24;MAPK6;CDK16;ATP1A1 |
| GTP-Rho binding | CDC42EP5;CDC42EP3;RTKN;ROCK2B;TRIOBP;TNFAIP1;CDC42EP1B;KCTD13;CDC42EP2 |
| Rac GTPase binding | DVL1;PKN1;PAK6;RAB7;PAK7;ITPKA;SRGAP2;EPS8;ARHGEF2 |
| androgen receptor binding | PRKCBB;DAXX;DDX5;FHL2;NRIP1;CTNNB1;CCNE1;RAN;RB1 |
| chromatin binding | Ar;SP110;MLL1;SSRP1A;CDC45;TADA2B;SSRP1;PAF1;CHD7 |
| histone binding | HAT1;NAP1L2;HIST1H3F;UHRF2;SMARCA4A;BRDT;USP49;BRD7;SIRT1 |
| histone deacetylase binding | PKN1;NACC2;XBP1;HES1;MYOCD;HIC1;RBBP4;CEBPA;TFAP4 |
| histone kinase activity (H3-T11 specific) | CHEK1;PKN1 |
| ligand-dependent nuclear receptor transcription coactivator activity | PPARGC1A;DCAF6;ZCCHC12;MED30;ATXN7L3;NCOA2;PPARGC1B;HMGA1-RS1;HELZ2 |
| protein binding | DAO;SUV420H2;DIEXF;NRG4;MUC7;CPNE1;HBZ;UQCRH;CCDC53 |
| protein kinase C activity | PRKCD;PKN1;PKN3;PRKCI;PRKCHA;PRKCQ;PRKCZ;PRKD3;PRKCB |
| protein kinase C binding | DACT3;PKP2;PRKCB;YWHAG;HAND2;TOP2A;CASQ2;HDAC7;HDAC7A |
| protein kinase activity | GUCY2C;BMPR2B;PDK3;MAPK8B;PLK5;LIMK1;SCYL1;NLK;CDC7 |
| protein serine/threonine kinase activity | RPS6KB1B;GSK3A;TAF1;PKN1;RIOK3;PINK1;SMOK2B;LMTK3;DCKL1B |
PKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKN1.
HOMER3; MID1; VIM; KRT15; CDR2; GOLGA2; KRT31
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