pkn1
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  • Official Full Name
  • protein kinase N1
  • Background
  • The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kina
Cat.#:PKN1-1744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PKN1, His-tagged
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Cat.#:PKN1-2709HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PKN1 protein, His & T7-tagged
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Cat.#:PKN1-704HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase N1, GST-His
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Cat.#:PKN1-72HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PKN1 protein, Flag-tagged, Biotinylated
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Cat.#:PKN1-12873MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PKN1 Protein
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Cat.#:PKN1-4482RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PKN1 Protein
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Cat.#:PKN1-1289HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Protein Kinase N1, GST-tagged
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Cat.#:PKN1-1363HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PKN1 cell lysate
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Involved Pathway

PKN1 involved in several pathways and played different roles in them. We selected most pathways PKN1 participated on our site, such as PIK-Akt signaling pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKN1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
CCND3; IKBKB; FGF22; PPP2R5C; PPP2R3A; ITGB7; PRKAA1; AKT2; VEGFB; TNXB
Salmonella infection
CCL4L2; RELA; CXCL8B.3; PFN1; NLRC4; WASL; MAPK12A; MAPK13; MYH9; IFNGR2

Protein Function

PKN1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKN1 itself. We selected most functions PKN1 had, and list some proteins which have the same functions with PKN1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CAMK2D2; ACTG2; MCM4; NADSYN1; TGFBR1; DNAH6; ILF2; PRKG1; P2RX4A; MTPAP
Function GTP-Rho binding
Related Protein PKN1; EXOC1; STXBP6; ROCK1; CDC42EP4A; CDC42EP4; ROCK2B; KCTD13; RTKN; CDC42EP1B
Function Rac GTPase binding
Related Protein RAB7A; PAK7; CORO1C; PAK3; NOXA1; RCC2; PAK2A; SRGAP2B; DOCK4; SRGAP2
Function androgen receptor binding
Related Protein PKN1; WIPI1; BRCA1; CCNE1; PRPF6; GRIP1; RNF4; RNF6; NCOA4; PIAS2
Function chromatin binding
Related Protein TCF7L1B; KIAA0101; TP53; NFIA; BAZ1B; ARID5A; KDM1A; PROP1; KDM8; HDAC7
Function histone binding
Related Protein BRD7; HIST1H3F; HAT1; BAZ2A; H3F3B; BRD1; UHRF1; BRDT; MCM2; CD1d1
Function histone deacetylase binding
Related Protein SP1; MAGEA2B; SRF; NKX3-1; RELA; NACC2; GLI3; SFPQ; MAGEA2; DHX36
Function histone kinase activity (H3-T11 specific)
Related Protein PKN1; CHEK1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein TSG101; SMARCD3; CARM1; HMGA1-RS1; SLC30A9; ZMIZ2; CCAR1; WDR77; NCOA3; ACTN4
Function protein binding
Related Protein BUB1B; CSTF3; SIK2; CLSTN1; S100A16; SUMO1; MLF1; PQBP1; GJD3; EGR1
Function protein kinase C activity
Related Protein PRKD3; PRKCD; PRKCDA; PRKD2; PRKCBB; PRKCA; PRKCI; PRKCQ; PRKCHB; PRKCHA
Function protein kinase C binding
Related Protein PARD3; GNB2L1; AKT1; MARCKS; PICK1; SDPR; HINT1; HDAC9; FLNA; PEA15A
Function protein kinase activity
Related Protein CSNK1A1; MAP2K1; PRKAA1; MAPK12B; PRKCBA; POMK; NTRK3A; NEK2; MAP3K4; STK26
Function protein serine/threonine kinase activity
Related Protein HIPK1; TESK2; STK25; PRKCDA; PIM3; SIK3; BMPR1BB; MAP2K2; PRKCBB; SRPK1A

Interacting Protein

PKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKN1.
HOMER3; MID1; VIM; KRT15; CDR2; GOLGA2; KRT31