| Description : |
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.8 kDa |
| AA Sequence : |
MASDAVQSEPRSWSLLEQLGLAGAD LAAPGVQQQLELERERLRREIRKEL KLKEGAENLRRATTDLGRSLGPVEL LLRGSSRRLDLLHQQLQELHAHVVL PDPAATHDGPQSPGAGGPTCSATNL SRVAGLEKQLAIELKVKQGAENMIQ TYSNGSTKDRKLLLTAQQMLQDSKT KIDIIRMQLRRALQAGQLENQAAPD DTQGSPDLGAVELRIEELRHHFRVE HAVAEGAKNVLRLLSAAKAPDRKAV SEAQEKLTESNQKLGLLREALERRL GELPADHPKGRLLREELAAASSAAF STRLAGPFPATHYSTLCKPAPLTGT LEVRVVGCRDLPETIPWNPTPSMGG PGTPDSRPPFLSRPARGLYSRSGSL SGRSSLKAEAENTSEVSTVLKLDNT VVGQTSWKPCGPNAWDQSFTLELER ARELELAVFWRDQRGLCALKFLKLE DFLDNERHEVQLDMEPQGCLVAEVT FRNPVIERIPRLRRQKKIFSKQQGK AFQRARQMNIDVATWVRLLRRLIPN ATGTGTFSPGASPGSEARTTGDISV EKLNLGTDSDSSPQKSSRDPPSSPS SLSSPIQESTAPELPSETQETPGPA LCSPLRKSPLTLEDFKFLAVLGRGH FGKVLLSEFRPSGELFAIKALKKGD IVARDEVESLMCEKRILAAVTSAGH PFLVNLFGCFQTPEHVCFVMEYSAG GDLMLHIHSDVFSEPRAIFYSACVV LGLQFLHEHKIVYRDLKLDNLLLDT EGYVKIADFGLCKEGMGYGDRTSTF CGTPEFLAPEVLTDTSYTRAVDWWG LGVLLYEMLVGESPFPGDDEEEVFD SIVNDEVRYPRFLSAEAIGIMRRLL RRNPERRLGSSERDAEDVKKQPFFR TLGWEALLARRLPPPFVPTLSGRTD ISNFDEEFTGEAPTLSPPRDARPLT AAEQAAFLDFDFVAGGCTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
